关键词: 药物动力学, 定域模型, 数学模型, 计算机程序

Abstract: Aim To establish and apply a new model called pharmcokinetic local model. Methods The local model of pharmacokinetics was deduced on the basis of multicompartment model, and phar macokinetical equation and several important patameters were obtained. Results The model could properly describe pharmacokinetic action of pharmaceuticals in organs or other tissues. Thereby,ambiguous explanation of multicempartment model about pharmaceutical in a specific tissue is replaced by the visual explanation of the new model. According to formulae of the model, we complited the computer program and made some calculations. The results show that the model can ideally explain experimental facts.

Key words: Pharmacokinetics, Local model, Mathematical model, Computer program