月见草胶囊治疗十二指肠溃疡近期疗效及治疗前后胃粘膜血流量、跨粘膜变化

中国临床药理学与治疗学 ›› 1996, Vol. 1 ›› Issue (2): 89-90.

月见草胶囊治疗十二指肠溃疡近期疗效及治疗前后胃粘膜血流量、跨粘膜变化

胡和平, 赵家松¹, 陈士葆, 张贤康, 张兴荣

第二军医大学长征医院消化内科,上海200003,
¹安徽省无为县人氏医院,238300

收稿日期:1996-05-20 修回日期:1946-07-13 发布日期:2020-12-03
作者简介:胡和平,医学硕士。

The effectiveness of Y uejiancao in the treatment of duodenal ulcer and the changes of GMBF,PD after treatment

Hu Heping, Zhao Jiasong¹, Chen Shibao, Zheng Xiankang, Zhang Xingrong

Department of Gastroenterology, Changzheng Hos pital, Second Military Medical University, Shanghai 200003

Received:1996-05-20 Revised:1946-07-13 Published:2020-12-03

摘要/Abstract

摘要： 目的观察富含亚油酸的月见草胶囊(以下简称月见草)治疗十二指肠溃疡近期效果,并初步探讨其作用机制。方法月见草(1.5g,3/d)与雷尼替丁(0. 15 g,2/d)分别治疗十二指肠溃疡31例、32例,疗程4周,观察治疗效果,并测定治疗前后胃粘膜血流量、跨粘膜电位。结果月见草与雷尼替丁治疗十二指肠溃疡4周治愈率分别为87.1%、87.5%,两者之间无明显差异(P>0.05),同时发现月见草治疗前后胃粘膜血流量、粘膜电位显著增加(P<0.05)。结论月见草对治疗溃疡病有良效,其作用机制可能与其大幅度增加胃粘膜血流量及跨膜电位有关。

关键词: 月见草, 亚油酸, 十二指肠溃疡, 胃粘膜血流量, 跨膜电位

Abstract: Aim This study aims mainly to explore the effectiveness and mechanism of Y uejiancao, a preparation abounding in linoleic acid (75%+) in the treatment of duodenal ulcer. Methods Yuejiancao (1.5g tid) was used respectively in 31 patients with dodenal ulcer and raniti-dine(0.15g,bid) in 32 matched control patients with the same disease for four weeks. The effectiveness of treament was obseverd by the examination of gastroendoscopy, and the values. of GMBF and PD were determined before and after treatment. Results A 87. 10% response. rate was acquired in Y uejiancao treated patients and a 87. 50% response rate in ranitidine group. There was no statistical difference between two groups. GMBF and PD increased significantly after treatment with Yuejiancao (P<0.05). Conclusion These findings sug-gest that Yuejiancao is an effective agent for treating peptic ulcerous disease. The effectire meckanism of Yuejiancao is mediated by significantly increasing GMBF and PD(P<0. 05).

Key words: Yuejiancao, linoleic acid, GMBF, PD, duodenal ulcer

中图分类号:

R975.6

胡和平, 赵家松, 陈士葆, 张贤康, 张兴荣. 月见草胶囊治疗十二指肠溃疡近期疗效及治疗前后胃粘膜血流量、跨粘膜变化[J]. 中国临床药理学与治疗学, 1996, 1(2): 89-90.

Hu Heping, Zhao Jiasong, Chen Shibao, Zheng Xiankang, Zhang Xingrong. The effectiveness of Y uejiancao in the treatment of duodenal ulcer and the changes of GMBF,PD after treatment[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1996, 1(2): 89-90.

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