关键词: 南山楂, 内皮细胞, 纤溶酶原激活物(t-PA), 纤溶酶原激活物抑制物(PAI), 胆固醇

Abstract: Aim The effect of crataegus cuneata (CC) on fibrinolysis of bovine aortic endothelial cells was studied. Methods The activity and level of tissuetype plasminogen activator (t-PA) from bovine aortic endothelial cells induced by hyperlipidemic serium, activity of plasminogen activator inhibitor (PAI) and level of cholesterol in bovine aortic endothlial cells were mea-sured. Result It was demonstrated that Crataegus cuneata promoted the release of t-PA from bovine aortic endothelial cells induced by hyperlipidemic series and increased its activity (contrast:1.032±0.412 IU/ml:CC(L):1.461+0.117 IU/ml, P<0.05;CC(H):1.539士0.304 IU/ml, p<0.05), but it inhibited singnificantly activity of PAI(control:12. 563±0. 637 IU/ml:CC(L): 10.397+0.341 IU/ml, P<0.01;CC(H): 10. 105士0.493 IU/ml, P<0.01). Crataegus cuneata could reduce the level of cholesterol in bovine aortic endothelial cells. Conclusion The. new evidence proved that crataegus cuneata was a stimulat to fibrinolysis of bovine aortic en-dothelial cells.

Key words: Crataegus cuneata, Endot helial cell, Tissuetype plasminogen activator, Plasminogen activator inhibitor, Cholesterol