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中国临床药理学与治疗学 ›› 1996, Vol. 1 ›› Issue (2): 99-100.

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复方盐酸伪麻黄碱溶液止咳作用及析方研究

赵秋贤, 袁秉祥, 袁媛, 张殿增, 高小利   

  • 收稿日期:1996-07-30 修回日期:1996-11-11 发布日期:2020-12-03
  • 作者简介:赵秋贤,女53岁,副主任药师,主要研究非处方用药的复方西药制剂和生物活性。

The Relieving Cough of Compound Pseudoephedrine and Analysis of the Effects of the Complex Prescription

Zhao Qiuxian, Yuan Bingxiang, Yuan Yuan, Zhang Dianzhen, Gao Xiaoli   

  1. Department of Pharmaceutics,First Affiliated Hospital, Xian 710061
  • Received:1996-07-30 Revised:1996-11-11 Published:2020-12-03

摘要: 目的 研究复方盐酸伪庥黄碱(盐酸伪麻黄碱+氢溴酸右美沙芬+扑尔敏)的止咳作用及组方的药理学基础。方法 通过小鼠 氨水引咳实验及析方进行研究。结果 单用氢溴酸右 美沙芬具有止咳作用,而单用盐酸伪麻黄碱和扑尔敏无明显止咳作用;氢溴酸右美沙芬与盐酸伪麻黄碱或扑尔敏合用均有协同止咳作用;复方盐酸伪麻黄碱三药间的协同作用大于它们的单用,并大于二药间的协同作用。结论 复方盐酸伪麻黄碱具有 止咳作用,其组份可表现出明显的协同作用。

关键词: 伪麻黄碱, 氢溴酸美沙芬, 扑尔敏, 镇咳

Abstract: Aim and Methods In order to identify and analysis the effects of compound pseudoephedrine on cough reaction, wihch consist of pseudoephedrine, dext romethorphan and chlerpheni-ramine. The effects of the complex on cough elicited by ammomia in mice were studed. Results The results showed that the complex and dextromethorphan could inhibit cough reaction, while pseudoephedrine and chler pheniramine could not. The effects of compound pseudoephedrine were more potent than that of any component, but not than complex of its two components. Conclusion The data indicated that compound pseudoephedrine could relieve cough reaction and each of its components had a synergistic action.

Key words: Compound pesudoephedrine, Pseudoephedrine, Dextromethorphan, Chlerpheniramine, Relieving cough

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