头孢噻肟在恶性血液病合并感染患者体内杀菌效价及临床疗效比较

中国临床药理学与治疗学 ›› 1997, Vol. 2 ›› Issue (1): 17-19.

头孢噻肟在恶性血液病合并感染患者体内杀菌效价及临床疗效比较

王睿, 陈迁, 陈孟莉, 楼方定¹, 朱军¹, 韩晓苹¹, 谭次娥², 裴保香², 王爱珍²

解放军总医院临床药理药学研究室,¹血液科,²临床药房北京100853

收稿日期:1996-04-17 修回日期:1997-01-16 出版日期:1997-03-26 发布日期:2020-12-04
作者简介:王睿,女,47岁,副研究员,硕士生导师,研究方向临床药理学。

Study on the serum bactericidal activity and clinical effects of cefotaxime in patients with hematopathy and infection complication

Wang Rui, Chen Qian, Chen Mengli, Lou Fangding¹, Zhu Jun¹, Han Xiaoping¹, Tan Cie², Pei Baoxiang², Wang Aizhen²

Chinease PLA General Hospital Dept of Clinical Pharmacology; ¹Dept of Heamotology; ²Clinical Dispensary , Beijing 100853

Received:1996-04-17 Revised:1997-01-16 Online:1997-03-26 Published:2020-12-04

摘要/Abstract

摘要： 目的对比观察头孢噻肟(CTX)与其他两种抗菌药物治疗方案对30例血液病合并感染患者杀菌活性(SBA)及临床疗效。方法 SBA采用微量稀释法测定,临床疗效根据临床治疗登记表按三级标准判定。结果与结论 头孢噻肟的临床反应最佳,杀菌作用时间维持较长,但对绿脓假单胞菌和阴沟肠杆菌杀菌作用较差;呱拉西林(PIP)与阿米卡星(AN)方案的抗菌谱广,但PIP杀菌作用时间较短,可考虑缩短给药间期,而AN可按一日一次给全日量的方案,以提高疗效减少不良反应;头孢哌酮(CPZ)可主要用于绿脓假单胞菌感染,也可用于其它细菌的混合感染,但给药间隔时间以一日三次为宜。

关键词: 恶性血液病, 血清杀茵活性, 头孢噻肟, 头孢哌酮, 哌拉西林, 阿米卡星

Abstract: Aim The serum bactericidal action (SBA)of cefotaxime and its clinical effect were observed and compared with two schedules of antimicrobial chemotherapy in patients with hematopathy complicated by infection.Methods Thirty patients in 3 groups were treated with cefotaxime (CTX), piperacillin plus amikacin (PIP + AN)and cefoperazone (CPZ)respectively.The SPA was determined by microdiluted method and the clinical effect was judged according to the records of symptoms and clinical effect was judged according to the records of symptoms and clinical findings recorded before and after treatment.Results In comparison with CPZ and PIP + AN, CTX had better SBA and longer antimicrobial time.As to against defferent strains of infection-causing bacteria the SBA of CTX to Ps aeruginose and E cloacea was weak, while PIP + AN had a broader antimicrobial spectrum, but the antibacterial time of PIP was short.Among the three antimicrobials there was no statistical defference in clinical effect.Conclusion To enhance the efficacy and reduce adverse reaction the dosing time should be regulated.It is recommended that piperacillin and cefoperazone be given three times daily, cefotaxime twice a day and amikacin once a day.

Key words: hematopathy serum bactericidal activity(SBA), cefotaxime, cefoperazone, piperacillin, amikacin.

中图分类号:

R978.11

王睿, 陈迁, 陈孟莉, 楼方定, 朱军, 韩晓苹, 谭次娥, 裴保香, 王爱珍. 头孢噻肟在恶性血液病合并感染患者体内杀菌效价及临床疗效比较[J]. 中国临床药理学与治疗学, 1997, 2(1): 17-19.

Wang Rui, Chen Qian, Chen Mengli, Lou Fangding, Zhu Jun, Han Xiaoping, Tan Cie, Pei Baoxiang, Wang Aizhen. Study on the serum bactericidal activity and clinical effects of cefotaxime in patients with hematopathy and infection complication[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1997, 2(1): 17-19.

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