通痹汤与氨甲喋呤联合治疗类风湿性关节炎疗效观察

中国临床药理学与治疗学 ›› 1997, Vol. 2 ›› Issue (1): 33-35.

通痹汤与氨甲喋呤联合治疗类风湿性关节炎疗效观察

高家骏, 佟大春¹, 朱禄来², 王和敏²

天津医科大学,天津300070;
¹江苏省邳州市第二人民医院221300;
²天津医大三院

收稿日期:1996-10-22 修回日期:1997-01-31 出版日期:1997-03-26 发布日期:2020-12-04
作者简介:高家骏,男,58岁,副教授,类风湿科副主任医师。曹获“医圣杯”国际中医药奖等。主要从事类风湿和风湿类疾病的临床和研究。佟大舂,男,56岁,副主任医师,主要研究心脑血菅血栓性疾病和风湿类疾病的防治。

Curative effect of tongpitang combined with methotrexate on rheumatoid arthritis

Gao Jiajun, Tong Dachun¹, Zhu Lulai², Wang Hemin²

Tianjin Medical University, Tianjin 300070;
¹Jiangsu Pizhou Second People's Hospital;
²The Third Hospital of Tianjin Medical University

Received:1996-10-22 Revised:1997-01-31 Online:1997-03-26 Published:2020-12-04

摘要/Abstract

摘要： 目的观察通痹汤与氨甲喋呤联合治疗类风湿关节炎疗效。方法治疗组采用中药通痹汤与氨甲喋呤联合治疗类风湿性关节炎(RA)79例,以凤湿液与氨甲喋呤联合治疗的40例RA作对照。其中治疗组18例,对照组9例。结果与结论 两组疗效均比文献所报告的单用氨甲喋呤疗效为佳。而通痹汤更具较强的抗炎镇痛及免疫调节作用,可使关节肿痛症状迅速消失,关节功能明显改善,晨僵时间消失或缩短,并随着关节炎症的减轻,使血液中IgG,IgM,IgA恢复正常,血沉下降曲线平稳,类风湿因子(RF)阴转率达67.57%。用药后撤停激素快,无反跳现象,副作用少。骨质修复作用明显,具有改善病情作用。其疗效明显优于对照组。

关键词: 类风湿性关节炎, 通痹汤, 氨甲喋呤

Abstract: Aim The efficacy of Tongpitang (a recipe consisting of 19 Chinese medicinal herbs)decoction in combination with methotrexate (MTX)against rheumatoid arthritis (RA)was to be observed.Methods Tongpitang (once daily)and MTX (7.5mg once weekly)were prescribed to 79 patients with RA for 3 months as a course.Serving as control, other 40 cases of RA were prescribed Fengshiye (a traditional Chinese medicinal preparation)combined with MTX.Eighteen cases from the Tongpitang group and nine cases from the control group were supplementally injected with Fengsiling.Results In comparison with the control, Tongpi-tang combined with MTX gave significant efficacy in relieving joint swelling and pain, shortening the morning stiffness, restoring IgG, IgM and IgA and dropping sedimentation.The negative conversion rate of rheumatoid factors reached 67.75%.There was no side- effect during hormone administration or rebound phenomeonafter stoping it.Conclusions Compared with single MTX of Fengshiye plus MTX, Tongpitang in combination with MTX gives the best curative effect in the treatment of rheumatoid arthritis.

Key words: rheumatoid arthritis, tongpitang, methotrexate

中图分类号:

R979

高家骏, 佟大春, 朱禄来, 王和敏. 通痹汤与氨甲喋呤联合治疗类风湿性关节炎疗效观察[J]. 中国临床药理学与治疗学, 1997, 2(1): 33-35.

Gao Jiajun, Tong Dachun, Zhu Lulai, Wang Hemin. Curative effect of tongpitang combined with methotrexate on rheumatoid arthritis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1997, 2(1): 33-35.

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