枸橼酸钾粒剂对低钾血症患者电解质的影响

中国临床药理学与治疗学 ›› 1997, Vol. 2 ›› Issue (2): 117-119.

枸橼酸钾粒剂对低钾血症患者电解质的影响

李传义, 周瑞海, 张德奎¹, 李爱国², 邵建华¹, 刘洪涛², 卜培丽

山东医科大学附属医院, 济南250012;¹山东省立医院;²济南军区总医院

收稿日期:1996-12-16 修回日期:1997-03-10 发布日期:2020-12-06
作者简介:李传义, 男, 58岁, 心脏内科教授, 主要从事应激性心肌病及高频心电图等研究。周瑞海, 男, 33岁, 副主任医师, 主要研究心血管内科学及临床药理学。

Effects of potassium citrate granuals on blood electrolyte levels of patients with hypokalemia

Li Chuanyi, Zhou Ruihai, Zhang Dekui¹, Li Aiguo², Xhao Jianhua¹, Liu Hongtao², Bu Peili

Department of cardiology, Affiliated Hospital of Shandong Medical University, Jinan 250012

Received:1996-12-16 Revised:1997-03-10 Published:2020-12-06

摘要/Abstract

摘要： 目的比较研究低钾血症患者口服枸橼酸钾颗粒剂及10%氣化钾口服液后血电解质水平变化。方法低钾血症患者随机分为枸橼酸钾颗拉剂组及氣化钾组, 每组100例, 分别口服枸蛛 5交钾颗轾剂, 2包/次（相当于2g氣化钾含钾量）, 每日3次, 及10%氣化钾口服液20 ml, 每日3次, 应用6天, 余治疗相似。用药第4及第6天空腹抽血测定血生化指标。结果枸橼醆钾颗粒剂具有良好的补钾效果, 对低钾血症患者用药3天及6天可使血清钾分别上升0. 65mmol/L及1. 05mmol/L, 其补钾疗效优于10%氣化钾口服液。枸橼酸钾颗粒剂不良反应少且轻微, 明显优于10%氣化钾口服液。结论枸轉醆钾颗粒剂补钾疗效肯定, 临床应用耐受性良好, 为理想的口服补钾制荆。

关键词: 低血钾症, 氣化钾, 柠檬酸钾

Abstract: Aim To observe the changes of electrolyte levels in hypokalemic patients after oral administration of potassium citrate granules and 10% potassium chloride (KCL) aolution. Methods Two hundred hypokalemic patients were randomly assigned into potassium citrate group and KCL group with 100 patients in each group. Patients in different group were given potassium citrate 2 packages tid and 10% KCL solution 20ml tid, respectively for 6 days, while other therapeutic measures were about the same. Fast serum electrolyte levels and other related biochemical parameters were determined. Results Potassium citrate granules had better potassium replacement effect than KCL solution. Serum potassium level was increased by 0. 65 and 1. 05 mmol/ L 3 and 6 days after the administration of potassium citrate granules. Potassium citrate granules had less side effects than KCL solution. Conclusions Potassium citrate granules is an ideal potassium replacement agent.

Key words: potassium chloride, potassium citrate, hypokalemia

中图分类号:

R977. 6

李传义, 周瑞海, 张德奎, 李爱国, 邵建华, 刘洪涛, 卜培丽. 枸橼酸钾粒剂对低钾血症患者电解质的影响[J]. 中国临床药理学与治疗学, 1997, 2(2): 117-119.

Li Chuanyi, Zhou Ruihai, Zhang Dekui, Li Aiguo, Xhao Jianhua, Liu Hongtao, Bu Peili. Effects of potassium citrate granuals on blood electrolyte levels of patients with hypokalemia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1997, 2(2): 117-119.