醋酸甲孕酮针剂对哺乳与非哺乳妇女的避孕作用

中国临床药理学与治疗学 ›› 1997, Vol. 2 ›› Issue (2): 81-84.

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醋酸甲孕酮针剂对哺乳与非哺乳妇女的避孕作用

郝转业, 陈素芳¹, 杨丹², 周惠恩, 罗世媛, 雷贞武², 邵庆翔, 桑国卫

浙江省医学科学院计划生育研究所, 杭州 310013

收稿日期:1997-02-17 修回日期:1997-03-24 发布日期:2020-12-06
作者简介:郝转业, 女, 44岁, 主治医师, 主要从事计划生育临床研究。桑国卫, 男, 56岁, 研究员, 中国临床药理专业委员会副主任委员, IUPHAR理事。

A clinical trial of progestin-only contraceptive injectable Depo Geston in Chinese lactating and non-lactating women

Hao Zhuanye, Chen Sufang, Yang Dan, Zhou Huien, Luo Shiyuan, Lei Zhenwu, Shao Qingxiang, Sang Guowei

Damily Planning Research Institute, Zhejiang Academy of Medical Sciences, Hangzhou, 310013

Received:1997-02-17 Revised:1997-03-24 Published:2020-12-06

摘要/Abstract

摘要： 目的观察醋酸甲孕酮微晶水混悬剂(MPA)的避孕作用、副反应和可接受性。方法 292名哺乳与非哺乳妇女对象在接受详细咨询并签署知情同意书后进入试验, 每三个月一次接受注射并随访, 观察期一年。结果用药期间无一例发生妊娠, 避孕有效率为100%。哺乳与非哺乳妇女一年总停针率分别为5. 05%和11. 4%。主要副反应为不规则出血, 哺乳妇女与出血有关的主诉发生率(16. 1%)明显高于非哺乳妇女(5. 1%, P< 0. 01)。未见其他严重副反应。结论 MPA是一种高效的长效避孕针, 经详细咨询后在中国妇女中可获得良好的可接受性, 尤其适合产后哺乳妇女使用。

关键词: 醋酸甲孕酮, 避孕剂, 哺乳

Abstract: A clinical trial of progestin-only contraceptive injectable Depo Geston in Chinese lactating and non-lactating women Hao Zhuanye Chen Sufang Yang Dan Zhou Huien Luo Shiyuan Lei Zhenwu Shao Qingxiang Sang Guowei (Damily Planning Research Institute, Zhejiang Academy of Medical Sciences, Hangzhou, 310013) Aim To evaluate the efficacy, side effects and acceptability of 3 monthly injectable contraceptive Depo Geston in lactating and non-lactating Chinese women. Methods All subjects were recruited in 3 clinics after giving datailed consultation and obtaining informed consent to receive im injection of Depo Geston at the 3 months interval for one year. Results No pregnancy occurred during one year study period. Overall discontin-uation rates for lactation and non-lactation women were 5. 05% and 11. 4%, respective-ly. The side effects mainly was irregular bleeding. The proportion of women complained of bleeding problems in non-lactation women(16. 1%) was higher than that in lactation women (5. 1%, P< 0. W). No other serious side-effects were observed. Conclusion Depo Geston is a highly effective, long-acting contraceptive, could have good acceptability after giving datailed advice. It is especially applicable to lactation women.

Key words: Depo Geston, DMPA, contraceptive, lactation

中图分类号:

R979. 21

郝转业, 陈素芳, 杨丹, 周惠恩, 罗世媛, 雷贞武, 邵庆翔, 桑国卫. 醋酸甲孕酮针剂对哺乳与非哺乳妇女的避孕作用[J]. 中国临床药理学与治疗学, 1997, 2(2): 81-84.

Hao Zhuanye, Chen Sufang, Yang Dan, Zhou Huien, Luo Shiyuan, Lei Zhenwu, Shao Qingxiang, Sang Guowei. A clinical trial of progestin-only contraceptive injectable Depo Geston in Chinese lactating and non-lactating women[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1997, 2(2): 81-84.

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醋酸甲孕酮针剂对哺乳与非哺乳妇女的避孕作用

A clinical trial of progestin-only contraceptive injectable Depo Geston in Chinese lactating and non-lactating women

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