西沙必利提高胆嚢结石患者胆囊收缩功能的临床观察

中国临床药理学与治疗学 ›› 1997, Vol. 2 ›› Issue (2): 89-91.

西沙必利提高胆嚢结石患者胆囊收缩功能的临床观察

傅贤波, 贾建文, 苗立英

北京医科大学第三医院, 北京 100083

收稿日期:1996-06-25 修回日期:1997-04-07 发布日期:2020-12-06
作者简介:傅贤皮, 男, 54岁, 教授, 《现代外科》杂志副主编, 研究生导师。研究方向：胆石症防治的临采与实验研究, 曾获卫生部、北京市、北医大科技成果笑, 中华医学会优秀论文笑。

A Clinical study on the effect of cisapride on improving gallbladder contraction function in patients with gallbladder stone

Fu Xianbo, Jia Jianwen, Miao Liying

Department of Surgery, Third Teaching Hospital, Beijing Medical University, Beijing 100083

Received:1996-06-25 Revised:1997-04-07 Published:2020-12-06

摘要/Abstract

摘要： 目的探讨西沙必利提高脬囊结石患者胆囊收缩功能及其防石和排石作用。方法应用B超对比研究口服西沙必利前后徤康对照组（9例）及胆囊结石组（21例）脬囊大小, 周长, 面积和脂餐后 60~120分钟间最大胆囊收缩率（PRGC)的差异。结果结石组PRGC(3(28. 6%±17. 3%)明显低于对照组（54. 7% ±11. 3%), P = 0. 0003。结石组空腹胆囊面积（18. 3± 11. 8 cm²)大于对照组 (12. 12 ± 2. 14 cm²), P < 0. 05。口服西沙必利前后两组胆囊周长, 面积的变化差异均无显著性。结石組PRGC服药后（41. 1% ± 14. 7%)较服药前（27. 5% ± 14. 7%)有明显提高, P = 0. 0134, PRGC提高者11/13(84. 6%)。两组PRGC的提高幅度与服药前PRGC呈负相关, r=-0. 5192, P = 0. 0272。结论胆囊结石患者的胆囊存在动力障崎, 空腹脬囊面积大于正常人而收缩功能明显低于正常。西沙必利对正常人和胆爱结石患者均能明显提高脂餐后胆囊收缩功能, 提高幅度与服药前PRGC成负相关。

关键词: 脬结石, 西沙必利, 脬囊

Abstract: Aim It was to be ascertained whether gallbladder contraction function could be improved by taking cisapride orally. Methods The size, circumference, area and the largest contraction rate of gallbladder (CRG) after fat meal were compared between the control group (9 subjects) and the stone group (21 cases), and between those before and after taking cisapride orally, by ultrasonography. Results There was a lower CRG in the stone group (28. 6 ± 17. 3%) as compared with that in the controls (54. 7% ± 11. 3%, P = 0. 0030). The mean area of fasting gallbladder was significantly larger in the stone group (18. 3 ± 11. 8 cm²) than in the controls (12. 1 ± 2. 14cm², JP< 0, 05), but no significant differences in circumference and area of the gallbladder before and after cisapride administration were found. There was a significant increase of CRG (41. 1% ± 14. 7%) in the stone group after taking cisapride in comparison with that before taking cisapride (27. 5% ± 14. 7%, P = 0. 0134). The increased CRG was seen in 11 out of 13 patients with gallbladder stone (84. 6%) . Based on the C|^G before taking cisapride, there was a negative correlation between increased degrees of CRG in two groups, (r =-0. 5192). Conclusions Cisapride has the effect on improving galjbladder contraction function after fat meal in subjects with or without gallblader stone, wi|h an effect rate of 81. 8%

Key words: cholelithiasis, gallbladder, cisapride

中图分类号:

R975. 5

傅贤波, 贾建文, 苗立英. 西沙必利提高胆嚢结石患者胆囊收缩功能的临床观察[J]. 中国临床药理学与治疗学, 1997, 2(2): 89-91.

Fu Xianbo, Jia Jianwen, Miao Liying. A Clinical study on the effect of cisapride on improving gallbladder contraction function in patients with gallbladder stone[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1997, 2(2): 89-91.