内皮素受体拮抗剂BQ-123对全脑缺血再灌流后脑组织损伤的保护作用

中国临床药理学与治疗学 ›› 1997, Vol. 2 ›› Issue (2): 98-100.

内皮素受体拮抗剂BQ-123对全脑缺血再灌流后脑组织损伤的保护作用

刘宏, 舒斯云, 包新民

第一军医大学珠江医院神经生物学研究室, 广州 510282

收稿日期:1997-01-21 发布日期:2020-12-06
作者简介:刘宏, 34岁, 男, 博士研究生, 主治医生, 汫师, 从事胲缺血损伤的机理及其昤治措施的研究。舒斯云, 60岁、女, 博士生导师, 珠江医院神经生物研究室主任, 广东神经科学学会理事长。从事神拉生物学和神经解剖学方面的研究, 曾获国家发明三等K等多项奖励。

Protective effect of BQ-123, an endotheiin receptor antagonist, on the brain damage caused by cerebral reperfusion in rats

Liu Hong, Shu Siyun, Bao Xinming

Institute of Neurobiology, Zhujiang Hospital, Guangzhou 510282

Received:1997-01-21 Published:2020-12-06

摘要/Abstract

摘要： 目的观察内皮素拮抗剂BQ-123对缺血再磾流后脑神经元损伤的保护作用。方法采用 Pusinelli的四血管阻断法（4VO)制作大鼠全脑缺血再灌流动物模型。在再灌流后30分钟给予 BQ-123(50μg/1μl, icv)。结果 BQ-123能增加缺血后海马CA1区神经元的存活数, 行为实验表明BQ-123治疗后大鼠的学习记忆能力有提高。结论内皮素受体拮抗剂BQ-123对全脑缺血再灌流引起海马区神经元损伤有部分保护作用。

关键词: 内皮素受体拮抗剂, 全脑缺血再灌流, 海马

Abstract: Aim The protectie effect of BQ-123 on the brain damage caused by cerebral ischemia reperfusion was to be observed. Methods The cerebral ischemia model was made by four-vessel occlusion method in SD rats. The reperfusion was performed for 72 hours, and then BQ-123 was injected intracerebrovertricularly in a volume of 0. 001ml at a dosage of 50μg/rat within 30 minutes after reperfusion. Results In the BQ-123 treated group, the number of survival neuron in the hippocampal CA1 was significantly greater than that in the untreated group (P<0. 01) and much smaller than that in the controls (P<0. 01). The behaviour test indicated that the reperfusion made the ability of study and memory in cerebral ischemia rats markedly reduced, and the BQ-123 treatment made the ability significantly improved (P <0. 01). Conclusion BQ-123 is useful in preventing the neuronal damage following the cerebral ischemia reperfusion in rats.

Key words: endotheiin receptor antagonist, BQ-123, neuronal damage, cerebral ischemia reperfusion

中图分类号:

R965

刘宏, 舒斯云, 包新民. 内皮素受体拮抗剂BQ-123对全脑缺血再灌流后脑组织损伤的保护作用[J]. 中国临床药理学与治疗学, 1997, 2(2): 98-100.

Liu Hong, Shu Siyun, Bao Xinming. Protective effect of BQ-123, an endotheiin receptor antagonist, on the brain damage caused by cerebral reperfusion in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1997, 2(2): 98-100.

参考文献

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