关键词: 维脑路通, 羟乙基芦, 丁药物动力学, 高效液相色谱法

Abstract: Aim The pharmacokinetics of venoruton and its chief compositions, various hydro xyethyl-rutin was observed in seven patients with cardio vascular disorder.Methods After int ravenous injection of uenoruton, the serum drug concent rations at regulart ime were measured by HPLC method with programme-controled sensitivity and the pharmacokine tical parameters were computed by the prog ramme PKBP-N 1.Results Venoruton in the patients was found to conform to an opened sing le-compartment model with t_1/2=5.8±1.7 h, Vc=111.1±32.0 L, AUC=37.5±10.8 mg/(h·L)and Cl=5.7±2.2 L/h.Hydroxyethyl rutin and dihydrox yethy l rutin confo rmed to the same model as venoruto n, but trihydrox yerthyl and tetrahydroxyethyl rutin conformed to an opened dubble-compartment model.The more hydroxyethy l number, the less t_1/2.Conclusion Venoruton's pha rmacokinetics is different with that of its composition.This HPLC method built in the test is a suitable for determining venoruton in the body.

Key words: venoruton, hydorxyethy l-rutin, Pharmacokinetics, HPLC