原发性下肢浅静脉曲张氧自由基损伤及AescuvenForte的拮抗作用

中国临床药理学与治疗学 ›› 1998, Vol. 3 ›› Issue (2): 120-121.

原发性下肢浅静脉曲张氧自由基损伤及AescuvenForte的拮抗作用

王春喜, 贾润英, 赵文光, 臧广生, 姚迪¹

白求恩医科大学第三临床学院; 长春 130031;
¹第一临床学院

收稿日期:1997-12-15 修回日期:1998-02-24 出版日期:1998-06-26 发布日期:2020-12-01

Observation of antagonism of aescuven forte tofree oxygen radical injuries in superf icial venons vericosis of legs

WANG Chun-Xi, JIA Run-Ying, ZHAO Weng-Guang, ZANG Guang-Sheng, YAO Di

TheThird Teaching Hospital, Bethuen Medical University, Chang Chun 130031

Received:1997-12-15 Revised:1998-02-24 Online:1998-06-26 Published:2020-12-01

摘要/Abstract

摘要： 目的探讨下肢浅静脉曲张患者氧自由基损伤及强力脉痔灵(AescuvenForte)对其损伤指标—血清过氧化氢酶(SOD),谷胱甘肽还原酶(GSH)及过氧化脂质(LPO)水平的影响。方法利用放射免疫测定法、DTNB直接法和TBA荧光法对60例原发性下肢浅静脉曲张患者进行用药前后血清SOD、GSH、LPO测定。结果本病患者血清中存在高水平的LPO及低水平的SOD、GSH,应用Aescuven Forte可有效地纠正血清SOD、GSH、LPO水平。结论测定SOD、GSH、LPO水平可用于了解治疗效果、指导临床用药;本研究提示拮抗自由基损伤可能是Aecuven Forte治疗下肢浅静脉曲张及其并发症的机制之一。

关键词: 原发性下肢浅静脉曲张, 过氧化脂质, 过氧化氢酶

Abstract: Aim Theantagonism oforal Aescuven forte tofree oxyg neradical injuries in superf icial venons vericosis of legs was to be observed.Methods Theserum levels of SOD, GSH, LPO in 60 patients with superf icial venous vericosis in legs were determined by radioimuno assay, DTNB method and TBA method.Results All patients had high level of serum LPO and low levels of serum SOD and GSH.All levels above could re turn tonormal aftereffective treat-ment with Ascuven Forte.Conclusion This study sug gested that thedeter mination of SOD, GSH, LPO is helpful to investig ate themechanism of illness and treatment, and to providereliable laboratory indexes for oral medicine use.

Key words: venous vericosis, aescuven forte, SOD

中图分类号:

R972.9

王春喜, 贾润英, 赵文光, 臧广生, 姚迪. 原发性下肢浅静脉曲张氧自由基损伤及AescuvenForte的拮抗作用[J]. 中国临床药理学与治疗学, 1998, 3(2): 120-121.

WANG Chun-Xi, JIA Run-Ying, ZHAO Weng-Guang, ZANG Guang-Sheng, YAO Di. Observation of antagonism of aescuven forte tofree oxygen radical injuries in superf icial venons vericosis of legs[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1998, 3(2): 120-121.

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