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中国临床药理学与治疗学 ›› 1998, Vol. 3 ›› Issue (2): 122-123.

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白头翁对利福平和异烟肼肝毒性的影响

路西明, 王建刚, 王学适, 吴银萍, 王淑英, 李艳   

  1. 洛阳医学高等专科学校药理教研室, 洛阳 471003
  • 收稿日期:1998-02-09 修回日期:1998-03-30 出版日期:1998-06-26 发布日期:2020-12-01
  • 作者简介:路西明, 男, 45岁, 副教授。

Protective Effect of Pulastiua chinensis on hepatic toxic injury induced by combining rifampin with isoniazidin mice

LU Xi-Ming, WANG Jian-Gang, WANG Xue-Ting, WU Ying-Ping, WANG Shu-Ying, LI Yan   

  1. Department of Pharmacology, Luoyang Medical College, Luoyang 471003
  • Received:1998-02-09 Revised:1998-03-30 Online:1998-06-26 Published:2020-12-01

摘要: 目的 观察白头翁对利福平、异烟肼致肝毒性的保护作用。方法 分别测定肝损害组和白头翁组小鼠的肝SGPT,肝指数,肝匀浆丙二醛以及肝细胞镜检,并与对照组比较。结果 白头翁组具有对抗利福平、异烟肼引起的SGPT增高和肝自由基的产生,减轻两者对肝细胞的损害。肝损害组与对照组和白头翁组比较均有显著性差异(P<0.01)。结论 白头翁对利福平、异烟肼致肝损害具有保护作用。

关键词: 白头翁, 肝保护, 抗痨药物, 肝损害

Abstract: Aim Theprotective Effect of pulastiua chinensis (PC)on hepatic toxic injury induced by combinig rifampin with isoniazid was to be observedin mice.Methods Theliver index, level of SGPT, content of MDA of liver homogenate, and degree of liver cell injury were invest igatedin mice.Results PC could decreasethelevel of SGPT, theconte nt of MDA and thedeg ree of liver injury (P<0.01).Conclusions PChas theprotective Effect on hepatic toxic injury induced by combining rifampin with isoniazidin mice.

Key words: pulsatiua chinensis, rifampin, isoniazid, protective effect of liver

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