关键词: 十全大补丸, 环孢菌素A, 肝毒性

Abstract: Aim The effect of Shiquandabu bolus (SQDB), a preparation of traditional Chinese medicaine on cycloporine (CsA) induced hepatotoxicity in rats was observed. Methods Wistar rats were separated into four groups: CsA (50 mg/kg), CsA(50 mg/kg) +SQDB (0.6 g/kg), CsA (50 mg/kg) + SQDB (0.3 g/kg) and normal saline (2% CMC Na) were separately given to the rats (ig, qd) for seven days, and then the parameters about liver function, glutamic-pyruvic transaminase (GPT) alkaline phosphatase (AKP) superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione strans ferase (GST) in serum, were determined, and pathologieal changes of liver tissue were observed by light microscope. Results In the CsA group, the levels of GPT and AKP in serum were higher significantly, but in the SQDB groups lower than those in the normal. The levels of SOD and GST were decreased more significantly in the three drug groups than in the normal but there was no significant difference in decrease between the SQDB and CsA groups. The levels of MDA in the two SQDB groups were higher but in the CsA group lower than in the normal. Conclusion SQDB has the effect of ferment reduction but no effect of clear an?ti oxidation and removing free radicals on CsA hepatotoxicity in rats.

Key words: Shiquandabu bolus, cyclosporine, hepatotoxicity