尿激酶联用硫酸镁治疗急性心肌梗塞的研究

中国临床药理学与治疗学 ›› 1998, Vol. 3 ›› Issue (3): 200-202.

尿激酶联用硫酸镁治疗急性心肌梗塞的研究

周红勤, 孙明¹, 胡婵, 李柳南², 刘志雄³

湖南省邵阳市第一人民医院心内科, 邵阳422001;
¹湖南医科大学湘雅医院;
²湖南医科大学附三院内科(现在美国迈阿密医疗中心);
³湖南省娄底地区卫校

收稿日期:1998-07-08 修回日期:1998-08-05 发布日期:2020-12-02
作者简介:周红勤, 男, 40 岁, 副主任医师, 主要研究心肺血管疾病。孙明, 男, 62 岁, 博士研究生导师, 中华心血管病学会委员, 《中华医学杂志》、《中华心血管病杂志》等刊物编委。

Study of urokinase combined with magnesium sulfate in the treatment of early acute myocardial infarction

ZHOU Hong-Qing, SUN Ming¹, HU Chan, LI Liu-Nan², LIU Zhi-Xiong³

Cardiovascular Department, ShaoyangFirst Municipal Pepoles Hospital, Shaoyang 422001;
¹Affiliated Xiang Ya Hospital of Hunan Medical University, Changsha 410008

Received:1998-07-08 Revised:1998-08-05 Published:2020-12-02

摘要/Abstract

摘要： 目的评价尿激酶(UK)联用硫酸镁(MS)治疗急性心肌梗塞(AMI)的临床疗效及安全性。方法 151 例AMI 住院患者随机分为UK +MS 组(UM 组, 76 例)和UK 组(75 例), 除UM 组在静滴UK 前15 min 开始加用MS 外, 余相同。结果 UM 组的再通率有高于UK 组趋势, 而5 周病死率、心力衰竭、梗塞后心绞痛、再梗塞及梗塞延展的发生率均明显低于UK 组(P 均＜0.01)。结论 UK 联用MS 治疗AMI 优于UK 疗法, MS 可作为一种安全有效的溶栓治疗辅助剂。

关键词: 尿激酶, 硫酸镁, 急性心肌梗塞, 溶栓疗法

Abstract: Aim To evaluate the efficacy and safety of urokinase (UK) combined with magnesium sulfate (MS) in the treatment of early acute myocardial infarction (AMI). Methods One hundred and fifty-one patients with AMI admitted to hospitals from December 1991 to May 1998 were randomly divided into two groups, 76 cases in UK plus MS (UM) group and 75 cases in UK group. In UM group, MS begen to be used 15 minites before intravenous drip of UK. Dose of UK in both groups was equivalent. The patency of infarct-elated coronary artery within three hours (including delayed patency)was assessed by uniform clinical criteria. Results The recanalization rate was higher in UM group than in UK group, but there was no statistical significance (73.7% vs 65.3%, P ＞0.05) five week mortality was 1.3% and 9.3% respectively. The difference was abvious (P＜0.05). Incidence of reperfusion arrhythmias was dramatically decreased (64.3 vs 87.8%, P＜0.01) in UM group. Moreover frequency of severe arrhythmias after thrombolysis was much lower in UM group than that in UK group (10.5% vs 28.0%, P＜0.01). In comparison with UK group, incidences of left heart failure (11.8% vs 25.3%) early postinfarction angina (3.9% vs 13.3%) reinfarction and infarct extension (2.6% vs 10.7%) were significantly reduced (all P＜0.05) in UM group, and frequency of cardiogenic shock (3.9% vs 8.0%) was lower, but it was not significant (P ＞0.05). Conolusions The efficacy of UK combined with is was superior to that of UK alone, for AMI and MS might be an effective and safe adjunct for thrombolytic therapy

Key words: urokinase, magnesium sulfate, acute myocardial infarction, thrombolytic ther-^apy

中图分类号:

R542.22

周红勤, 孙明, 胡婵, 李柳南, 刘志雄. 尿激酶联用硫酸镁治疗急性心肌梗塞的研究[J]. 中国临床药理学与治疗学, 1998, 3(3): 200-202.

ZHOU Hong-Qing, SUN Ming¹, HU Chan, LI Liu-Nan², LIU Zhi-Xiong³. Study of urokinase combined with magnesium sulfate in the treatment of early acute myocardial infarction[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1998, 3(3): 200-202.

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