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中国临床药理学与治疗学 ›› 1998, Vol. 3 ›› Issue (4): 275-278.

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抗衰灵口服液对小鼠学习记忆的改善作用

高美华, 李静美, 杨军1, 王静1   

  1. 合肥神鹿药业有限公司,合肥230041;
    1安徽省医学科学研究所
  • 收稿日期:1998-08-17 修回日期:1998-09-25 出版日期:1998-12-26 发布日期:2020-12-01

Effect of Kangshuaiming mixture on ability of learning and memory of mice

GAO Mei-Hua, LI Jing-Mei, YANG Jun1, WA NG Jing1   

  1. Hefei Shenlu Pharmacetical Ltd.Co.Hefei 230041;
    1Anhui Institute of Medical Sciences
  • Received:1998-08-17 Revised:1998-09-25 Online:1998-12-26 Published:2020-12-01

摘要: 目的 观察抗衰灵口服液对多种化学物质所致学习记忆障碍的影响。方法 给予各种化学试剂造成小鼠学习记忆功能障碍,采用一次性被动回避反应跳台法和避暗法,以及方向辨别性水迷宫法观察受试药的改善作用。结果 抗衰灵口服液能明显减少东莨菪碱所致获得性记忆障碍小鼠的错误次数、增强戊巴比妥钠引起的空间记忆障碍小鼠的学习记忆能力,对抗亚硝酸钠造成的小鼠记忆巩固不良和40 %乙醇引起的小鼠记忆再现障碍。结论 抗衰灵口服液具有多方面改善智力的作用。

关键词: 抗衰灵口服液, 小鼠, 学习记忆, 跳台法, 避暗法, 水迷宫法

Abstract: Aim The effect of Kang shuailing mixture on ability of learning and memory of mice was observed.Methods Mice were given different chemical substances to build special experimental models.With the methods of passive avoidance reaction (stePdown test,stePthrough test and labyrinth test)the action of Kang shuaining mixture was observed.Results The experiment show ed that Kang shuaining mixture could decrease the learning disorder caused by scopolamine,promote the ability of memory of mice with spaceorientation disorder caused by per tobarbital sodium,and antagonize disorder of memory consolidation induced by sodium nitrite and disorder of memory reappearance induced by ethanol.Conclusion Kang shuaining mixture possess obvious effects on learning and memo rypromotion at different levels.

Key words: Kangshuaining mixture, mice, memory, step down test, step through

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