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中国临床药理学与治疗学 ›› 1998, Vol. 3 ›› Issue (4): 282-284.

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角膜胶原膜的研制及临床应用

赵世红, 郭连珍, 侯勤黄, 王凯慧1   

  1. 哈尔滨市第一医院眼科,哈尔滨 150010;
    1哈尔滨医科大学基础医学院 150086
  • 收稿日期:1998-10-19 修回日期:1998-11-11 出版日期:1998-12-26 发布日期:2020-12-01
  • 作者简介:赵世红,女,硕士,主治医师,从事眼科专业研究。

The preparation of corneal collagen shield and its clinical application

ZHAO Shi-Hong, GUO Lian-Zheng, HOU Qin-Ying, WANG Kai-Hui1   

  1. The First Hospital of Harbin,150010;
    1Harbin Medical University,150086
  • Received:1998-10-19 Revised:1998-11-11 Online:1998-12-26 Published:2020-12-01

摘要: 目的 研究角膜胶原膜的制做方法及其在单纯疱疹病毒性角膜炎(HSK)治疗中的应用。方法 从猪巩膜中提取胶原采用离心干燥成膜法制成角膜胶原膜,在无环鸟苷药液内浸泡后用治疗单纯疱疹病毒性角膜炎。结果 应用浸泡无环鸟苷(ACV)药液的胶原膜治疗组病灶平均愈合时间9.45天,局部滴无环鸟苷药液组病灶愈合平均时间14.36天,两组治愈和有效率分别为90.63%,65.63%和96.88%,81.25%差异具有显著性(P<0.05)。结论 浸泡无环鸟苷药液后的胶原膜在单纯疱疹病毒性角膜炎的治疗中将具有较好的应用前景。

关键词: 角膜胶原膜, ACV, HSK

Abstract: Aim The method of preparing corneal collagen shield and its the rapeutic effect teating Herpes Simplex Kera tit is (HSK)w ere studied.Methods Collagen was extracted from sclera of pig.Using centrifugal method to make corneal collagen shield.After soaked with Aciclovir (ACV),the corneal collagen shields w ere used for treating HSK.Results The results indicate that in the grouPof corneal collagen shield soaked with ACV the average recover time of cornea was 9.45 days,in the grouPof instillation of ACV eye drops the average recover time was 14.36 days.The curerate and effective rate of the two groups were 90.63%、65.63% and 96.88%、81.25%(P<0.05).Conclusions The corneal collagen shield immersed with ACV will play an important role in HSK treatment.

Key words: corneal collagen shield, ACV, HSK

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