Docetaxel单用和与batimastat 联用对人肺巨细胞癌模型的抗肿瘤作用

中国临床药理学与治疗学 ›› 1999, Vol. 4 ›› Issue (3): 185-190.

Docetaxel单用和与batimastat 联用对人肺巨细胞癌模型的抗肿瘤作用

顾斌, 吴德政, 梁月琴, 吕焕章, 高洪志

北太平路医院临床药理科, 北京 100039

收稿日期:1999-08-15 出版日期:1999-09-26 发布日期:2020-11-27
作者简介:顾斌, 男, 33 岁, 助理研究员, 医学博士;吴德政, 男, 65 岁, 研究员, 博士生导师, 主要从事临床药理和肿瘤药理学研究

Antitumor effects of docetaxel alone and in combinat ion with batimastat in human giant cell carcinoma of the lung model

GU Bin, WU De-Zheng, LIANG Yue-Qin, LU Huan-Zhang, GAO Hong-Zhi

Department of Clinical Pharmacology, North Taiping Road Hospital, Beijing 100039

Received:1999-08-15 Online:1999-09-26 Published:2020-11-27

摘要/Abstract

摘要： 目的研究docetaxel 和batimastat (BB-94)对人肺巨细胞癌(PG) 的作用并与阿霉素做比较。方法和结果 docetaxel 对PG 细胞有明显的细胞毒作用, BB-94 则无此作用, 而且BB-94 体外不能增强docetaxel 的细胞毒作用。体内在早期PG 瘤裸鼠模型上应用最大耐受量的docetaxel 和阿霉素(iv, q4d×3) 、BB-94 (30 mg·kg^-1, ip, qd×20), docetaxel 联用 BB-94 的抑瘤率(97.3 %)大于阿霉素联用BB-94 (86.5 %)、docetaxel (92.0 %)、阿霉素(74.0 %)和BB-94 (31.0 %)。docetaxel 对晚期PG 瘤也具有明显的抑制作用, 而且强于阿霉素。结论 docetaxel 对PG 瘤裸鼠模型具有显著抑制作用, 联用BB-94 可增强docetaxel的抗肿瘤作用。

关键词: docetaxel batimastat, 肺肿瘤, 联合药物治疗

Abstract: Aim To study the effect of docetaxel alone and in combination with batimastat (BB-94)on human giant cell carcinoma of the lung (PG).Methods and Results Growth curve analysis, MTT assay and clonogenic assay were used to determine the cytotoxic effect of docetaxel or/and BB-94 on PG cell in vitro.The results showed that docetaxel but not BB-94 had a significantcy to toxicity, and the effect of docetaxel was not enhanced by BB-94.In early stage PG tumor model, obvious antitumor effect of docetaxel or doxorubicin doxorubicin given iv at maximum tolerated dose(MTD, docetaxel 20 mg·kg^-1, dox orubicin, 6 mg·kg^-1)every 4 days for 3 injections(q4d×3), even of BB-94 (30 mg·kg^-1, ip, qd×20)was observed. Tumo rg rowth inhibition was greater for Docetaxel-bat imastat (97.3 %)than for doxorubicin-batimastat (86.5 %), docetaxel (92.0 %), doxorubicin (74.0 %)and BB-94(31.0 %).Docetaxel also showed active against advanced stage PG tumor in dose-dependeNTManner, and was more effective at MTD than do xorubicin with 4/5 regression, 55.8 day stumor growth delay and 2.8 log 10 tumor cell kill.Conclusion Docetaxel is an effectivecy to toxic new drug against PG tumor, and BB-94 can enchance the antitumor activity of docetaxel.

Key words: docetaxel, BB-94, lung neoplasms, combination drug therapy

中图分类号:

R979.1

顾斌, 吴德政, 梁月琴, 吕焕章, 高洪志. Docetaxel单用和与batimastat 联用对人肺巨细胞癌模型的抗肿瘤作用[J]. 中国临床药理学与治疗学, 1999, 4(3): 185-190.

GU Bin, WU De-Zheng, LIANG Yue-Qin, LU Huan-Zhang, GAO Hong-Zhi. Antitumor effects of docetaxel alone and in combinat ion with batimastat in human giant cell carcinoma of the lung model[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1999, 4(3): 185-190.

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