肝缺血再灌注脂质过氧化损伤及维生素C 的保护作用1

中国临床药理学与治疗学 ›› 1999, Vol. 4 ›› Issue (3): 198-200.

肝缺血再灌注脂质过氧化损伤及维生素C 的保护作用¹

王万铁, 林丽娜², 徐正介, 李东², 王宗敏³

温州医学院病理生理教研室, 温州 325003; ²附属一院麻醉科; ³附属二院

修回日期:1999-07-06 出版日期:1999-09-26 发布日期:2020-11-27
作者简介:王万铁, 男, 35 岁, 副教授, 主要从事脏器缺血再灌注损伤机理及防治研究。
基金资助:
1 浙江省教委、卫生厅科研基金资助项目

Lipid peroxidation injury of liver after ischemia-reperfusion and protection effect of vitamin C

WANG Wan-Tie, LIN Li-Na, XU Zheng-Jie, LI Dong, WANG Zong-Min

Department of pathophysiology, Wenzhou Medical College, Wenzhou 325003

Revised:1999-07-06 Online:1999-09-26 Published:2020-11-27

摘要/Abstract

摘要： 目的探讨维生素C(VitC)预防及治疗肝缺血再灌注脂质过氧化损伤的作用。方法制备家兔肝缺血再灌注模型, 检测血浆及肝组织脂质过氧化产物丙二醛(MDA)和维生素E(VitE), 动态观察肝形态学变化, 并应用0.25 g · kg^-1VitC 防治脂质过氧化损伤。结果肝缺血再灌注期间, MDA 明显增高, VitE 显著下降, 肝形态学发生异常变化;缺血前及再灌注时应用VitC, 血、肝MDA 均显著低于对照组(P<0.01), VitE 均明显高于对照组(P<0.01), 肝形态学异常改变明显减轻。结论 0.25 g · kg^-1 VitC 能抑制或减轻肝缺血再灌注脂质过氧化损伤。

关键词: 肝缺血再灌注, 脂质过氧化损伤, 维生素C

Abstract: Aim To explore the treating effect of vitamin C(VitC)on lipid peroxidation injury of liver after ischemiz-reperfusion.Methods A model of hepatic ischemia-reperfusion in rabbits was established to invest igate the alterat ions of lipid peroxide by measuring malo ndialdehyde (MDA)and vitamin E (VitE)in plasma or liver t issue, and to observe the morpholog icachanges of hepatocytes. A large dose of VitC was given to the model aninals to observe its preventing and treating effects on lipid peroxidation injury of the liver (VitC in a dose of 0.25 g ·kg^-1).Results The degree of lipid peroxidation was streng thened and the morphological changes of hepatocy tes were more obvious during hepatic ischemia-reperfusion when VitC was given before ischemia and before reperfusion, respectively, the degree of lipid peroxidation was remarkabley weakened and the abnormal changes of hepatocytes weResig nificantly at tenuated.Conclusion VitC in a dose of 0.25 g · kg^-1 would inhibit or ameliorate lipid peroxidation injury of liver after ischemia-reperfusion.

Key words: hepatic ischemia-reperfusion, lipid peroxidation injury, vitamin C

中图分类号:

R962

王万铁, 林丽娜, 徐正介, 李东, 王宗敏. 肝缺血再灌注脂质过氧化损伤及维生素C 的保护作用¹[J]. 中国临床药理学与治疗学, 1999, 4(3): 198-200.

WANG Wan-Tie, LIN Li-Na, XU Zheng-Jie, LI Dong, WANG Zong-Min. Lipid peroxidation injury of liver after ischemia-reperfusion and protection effect of vitamin C[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1999, 4(3): 198-200.

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肝缺血再灌注脂质过氧化损伤及维生素C 的保护作用¹

Lipid peroxidation injury of liver after ischemia-reperfusion and protection effect of vitamin C

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