1 Vozeh S,Muir KT,Sheiner LB,et al. Predicting individual pheny to in do sage.J Pharmacokine t Bio-pharm,1981;9:131 2 MartinE,Tozer TN,Sheiner LB,et al. The clinical pharmacokinetics of phenytoin.J Pharma cokinet Biopharm,1977;5:579 3 张扬达,宋继芬,周怀梧,等.苯妥英钠剂量方案个体化方法的研究.中国临床药理学杂志,1989;5:216 4 周怀梧. 数理医药学.第1 版.上海:上海科学技术出版社,1983:150 5 李庆扬,王能超,易大义.数值分析.第3 版.武汉:华中理工大学出版社,1988:172 6 Sheiner LB,Rosenberg B,Marathe VV.Estimation of population characteristics of pharmacokinetic parameters from routine clinical data. J Pharmacokinet Biopharm,1977;4:445 7 周怀梧. Michaelis-Menten 消除动力学稳态特性的数学研究.中国药理学报,1986;7:385 8 周怀梧,景荣荣,裘祖强.Michaelis-M enten 消除动力学稳态特性的模拟研究.中国药理学报,1986;7:483 9 南京大学数学系.最优化方法.第1 版.北京:科学出版社,1978:111 10 LuddenTM,Beal S L,Peck CC,et al. Evaluation of aBayesianreg ression-analysis computer program for predicting phenytoin concentration. Clin Pha rmacy,1986;5:580 11 Godley PJ,Ludden TM,Clementi WA,et al. Evaluationof aBayesianre gression-analy siscomputer programusingnon-steady-statephenytoin concent rations.Clin Pharmacy.1987;6:634 12 吕明,周怀梧,宋继芬.米氏消除型总体药物动力学程序.中国药理学报,1990;11:85 13 芮建中,蔡明虹,储小曼,等.NONMEM 法估算中国癫痫患者苯妥英的群体药动学参数.药学学报,1995;30:172 14 Davis AL,Begg EJ,Kennedy M C,et al. Application of a simplifiedmethod to determine bio availability of an oral dose of pheny to in. J Pharmacokinet Biopharm,1993,21:1 95 |