肾病5号对腺嘌呤致大鼠慢性肾炎模型的治疗研究

中国临床药理学与治疗学 ›› 1999, Vol. 4 ›› Issue (4): 282-285.

肾病5号对腺嘌呤致大鼠慢性肾炎模型的治疗研究

周全荣, 戴诗文¹, 王绪平, 张伟敏, 徐淑妍, 肖成伟

浙江省公安边防总队医院,杭州 310004;¹浙江省中医药研究院

收稿日期:1999-09-06 发布日期:2020-11-27
作者简介:周全荣,男。46岁,副主任医师,副院长。

Therapeutic effect of "shen-bing No5" on adenine-induced chronic nephritis in rats

ZHOU Quan-Rong, DAI Shi-Wen, WANG Xu-Ping, ZHANG Wei-Min, XU Shu-yan, XIAO Cheng-Wei

The Hospital of Zhejiang's Frontier Defence General Army of Public Security, Hangzhou 310004

Received:1999-09-06 Published:2020-11-27

摘要/Abstract

摘要： 目的研究肾病5号对腺嘌呤造成的大鼠慢性肾炎模型的治疗作用。方法采用腺嘌80Mg·kg^-1给大鼠每日灌胃造成慢性肾炎模型。观察肾病5号对慢性肾炎大鼠血TP、BUN、Cr、Na⁺、24h尿蛋白、尿BUN、尿Cr等生化指标,以及对肾脏病理组织学的影响。结果与慢性肾炎模型比较, 肾病5号组能使24 h尿蛋白、BUN含量及血清BUN、Na⁺水平明显下降(P<0.05), 肾重及肾重指数与模型组比较有非常显著的差异(P<0.01), 镜下见其可减轻肾小菅扩张程度、使间质内炎细胞浸润减少,病理变化得到明显改善。结论肾病5 号具有改善肾功能,防治慢性肾炎的作用。

关键词: 肾病5号, 慢性肾炎, 腺嘌

Abstract: Aim The therapeutic effect of“shen-bing No 5”,a preparation of traditional Chinese medicine on adenine-induced chronic nephritis in rats was studied. Methods Chronic nepbritis in rats was induced by giving adenine 80 mg·kg ^-1·d^-1 orally. The model rats were treated by“shen-bing No 5”in different dosages. Levels of urea nitrogen(BUN), creatinine (Cr), total protein(TP),and Na⁺ in serum and or urine were detected and the changes of kidney were obseraed.Results The “shen-bing No 5”markedly lowered the levels of urine protein in 24 hours, BUN in urine and BUN, Na⁺in serum (P<0. 05). The kidney weight and the index of kidney weight were significantly different (P<0.01) from those in the adenine model group. The pathological examination of kidneys showed the“ shen-bing No 5” also could alleviate the expansion of renal tubules and diminish the interstitial inflammatory cell. Conclusion “Shen-bing No 5”can improve the renal function and delay the development of chronic nephritis.

Key words: "Shen-bing No 5", chronic nephritis, Adenine

中图分类号:

R285.5

周全荣, 戴诗文, 王绪平, 张伟敏, 徐淑妍, 肖成伟. 肾病5号对腺嘌呤致大鼠慢性肾炎模型的治疗研究[J]. 中国临床药理学与治疗学, 1999, 4(4): 282-285.

ZHOU Quan-Rong, DAI Shi-Wen, WANG Xu-Ping, ZHANG Wei-Min, XU Shu-yan, XIAO Cheng-Wei. Therapeutic effect of "shen-bing No5" on adenine-induced chronic nephritis in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1999, 4(4): 282-285.

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