关键词: 瑞巴匹特, 药物动力学, 高效液相色谱

Abstract: Aim The pharmacokinetics of rebamipide domestic and imported pro ducts in 27 patients with peptic ulcer was investigated.Methods The rebamipide concentrations in plasma were determined by high performance liquid chromatographic method following a single oral dose of 600 mg rebamipide made either in China or in Japan.The pharmaco kinetic parameters were computed with PKBP-N₁ program.Results Following a single oral dose of rebamipide, the concentration-time curves of the domestic and imported products fitted to two compartment open model.There was no significant difference in each pharmacokinetic parameters between the two product s(P>0.05). C_max of domestic and imported rebamipide tablet were (0.56±0.24) and (0.59±0.29)mg·L^-1,with that t_max were (1.75±0.92)and (1.98±1.05) h, t_1/2(β) were (1.86±1.38)and (1.93±1.45)h, AUC_0~∞ were (2.48±1.06) and (2.62±1.35)mg·h·L_-1. Conclusion The pharmacokinetics of the two products are similar.

Key words: rebamipide, pharmacokinetics, high performance liquid chromatographic