国产司帕沙星体外抗菌作用研究

中国临床药理学与治疗学 ›› 2001, Vol. 6 ›› Issue (3): 196-199.

国产司帕沙星体外抗菌作用研究

王睿, 方翼, 刘皈阳, 陈迁, 方向群¹, 刘庆锋¹

解放军总医院临床药理研究室, ¹呼吸科, 北京 100853

收稿日期:2001-01-08 修回日期:2001-02-26 出版日期:2001-06-26 发布日期:2020-11-30
作者简介:王睿, 女, 硕士研究生导师, 从事抗生素研究。

Study in vitro of antimicrobial activity of domestic sparfloxacin

WANG Rui, FANG Yi, LIU Gui-Yang, CHEN Qian, FANG Xiang-Qun¹, LIU Qing-Feng¹

Dept of Clinical Pharmacology, ¹Dept of Pulmonary Diseases, Chinese PLA General Hospital, Beijing 100853

Received:2001-01-08 Revised:2001-02-26 Online:2001-06-26 Published:2020-11-30

摘要/Abstract

摘要： 目的比较司帕沙星(SPLX) 与洛美沙星(LMLX)、环丙沙星(CPLX)、氧氟沙星(OFLX) 和依诺沙星(ENX) 的体外抗菌活性。方法采用琼脂平板稀释法测定MIC, 以NCC Ls 标准判读敏感性。结果 SPLX 对受试菌的抗菌活性最强, MIC₉₀为2 mg·L^-1, 而LMLX、CPLX、OFLX 和ENX 的MIC₉₀ 分别为16、16、16 和32 mg·L^-1。SPLX 的MIC 几何均数(MIC_g) 显著低于LMLX、OFLX 和ENX, 略低于CPLX。SPLX 对革兰氏阳性球菌的敏感率为100%, 明显高于其它对照药物。结论 SPLX 比其他氟喹诺酮类抗菌谱扩大、抗菌活性增强。

关键词: 司帕沙星, 体外抗菌活性

Abstract: Aim To study in vitro the antibacterial activity of domestic sparfloxacin (SPLX) and compare it with other four quinolones including lomefloxacin (LMLX), ciprof lox acin (CPLX), ofloxacin(OFLX) and enox acin(ENX).Methods Minimal inhibitory concentrations(MIC) were determined by means of agar disk dilution method.The susceptibility was defined acco rding to NCCLs.Results SPLX was the most active one in the quinolones against all tested st rains. Its MIC₉₀ was less or equal to 2 mg·L^-1, while the MIC₉₀ of LMLX、CPLX、OFLX and ENX were 16、 16、16 and 32 mg·L^-1, respecti rely.The geomet ric means of MIC (MIC_g) of SPLX (0.179 mg·L^-1) were significant lower than MIC_g of LMLX、OFLX and ENX and slightly lower than that of CPLX.The susceptible rate of G⁺ cocci was 100%, significantly higher than that of controlled quinolones.Conclusion The antibacterial spectrum of SPLX is wider and the activity against clinical isolates is higher than that of other quinolones.

Key words: sparfloxacin, antibacterial activity in vitro

中图分类号:

R978.1

王睿, 方翼, 刘皈阳, 陈迁, 方向群, 刘庆锋. 国产司帕沙星体外抗菌作用研究[J]. 中国临床药理学与治疗学, 2001, 6(3): 196-199.

WANG Rui, FANG Yi, LIU Gui-Yang, CHEN Qian, FANG Xiang-Qun, LIU Qing-Feng. Study in vitro of antimicrobial activity of domestic sparfloxacin[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2001, 6(3): 196-199.

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