茶多酚对家兔阳离子化牛血清白蛋白肾炎模型的治疗作用1

中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (3): 217-220.

茶多酚对家兔阳离子化牛血清白蛋白肾炎模型的治疗作用¹

洪宗元, 郑青山², 桂常青³, 宋建国³, 孙瑞元²

中国科技大学生命科学学院, 合肥 230027;
²安徽省药物临床评价中心, 芜湖 241001;
³皖南医学院药理教研室, 芜湖 241001

收稿日期:2001-10-18 修回日期:2001-01-07 发布日期:2020-12-01

Therapeutic effect of tea polyphenols on cationic bovine serum albumin glomerulonephritis in rabbits¹

HONG Zong-Yuan, ZHENG Qing-Shan², GUI Chang-Qing³, SONG Jian-Guo³, SUN Rui-Yuan²

School of Life Science, University of Science and Technology of China, Hefei 230027;
²Anhui Provicial Center for Drug Clinical Evaluation, Wuhu 241001;
³Department of Pharmacology, Wannan Medical College, Wuhu 241001

Received:2001-10-18 Revised:2001-01-07 Published:2020-12-01
Contact: HONG Zong-Yuan, correspondent, male, Ph.D, associate professor, main re-search fieldis renal pharmacology and pharmacogenomics. Tel:86-551-3655324 E-mail:zongyhong @163.net.
Supported by:
1 Natural Scientific Foundation of Anhui Province (No 98444332) and the Educational Foundation of Anhui Province (No 98JL042).

摘要/Abstract

摘要： 目的: 探讨茶多酚对家兔阳离子化牛血清白蛋白模型(C-BSA) 肾炎的治疗作用。方法: 按文献方法复制家兔C-BSA 肾小球肾炎模型, 并用3 种不同剂量的茶多酚 (30, 100 和300 mg·kg^-1) 给C-BSA 肾小球肾炎模型兔灌胃, 每日1 次, 连续 14 d 。结果: 茶多酚不仅可以显著减少模型兔 24 h 尿蛋白分泌, 降低血清肌酐和尿素氮水平, 而且可以减轻肾小球病理损害, 并且存在明显的量效关系。结论: 茶多酚对家兔C-BSA 模型肾炎具有明显的治疗作用。

关键词: 茶多酚, 阳离子化牛血清白蛋白肾小球肾炎, 家兔, 动物模型

Abstract: AIM: To investigate the therapeutic effect of tea polyphenols (TP) on cationic bovine serum albumin (C-BSA) glomerulonephritis.METHODS: C-BSA glomerulonephritic model was inducedin rabbits.TP in three different doses (30, 100 and 300 mg·kg^-1) was ad-ministered (ig) once daily for 14 days.RESULTS: TP not only significantly reduced the urinary protein excretion, decreased blood urea nitrogen (BUN) and plasma creati-nine (Cr) levels, but also significantly relieved gloermular lesions in the rabbits treatedand there was a significant dose-dependent relationship between high dosage (300 mg·kg^-1) and low dosage (30 mg·kg^-1).CONCLUSION: TP can reduce proteinuria, suppress the development of glomerular impairments, and ameliorate the kidney function of rabbits with C-BSA glomerulonephritis.

Key words: tea polyphenols, C-BSA glomeru-lonephritis, rabbit, animal model

中图分类号:

R965.1

洪宗元, 郑青山, 桂常青, 宋建国, 孙瑞元. 茶多酚对家兔阳离子化牛血清白蛋白肾炎模型的治疗作用¹[J]. 中国临床药理学与治疗学, 2002, 7(3): 217-220.

HONG Zong-Yuan, ZHENG Qing-Shan, GUI Chang-Qing, SONG Jian-Guo, SUN Rui-Yuan. Therapeutic effect of tea polyphenols on cationic bovine serum albumin glomerulonephritis in rabbits¹[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2002, 7(3): 217-220.

参考文献

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茶多酚对家兔阳离子化牛血清白蛋白肾炎模型的治疗作用¹

Therapeutic effect of tea polyphenols on cationic bovine serum albumin glomerulonephritis in rabbits¹

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