骨化三醇对腹透患者钙磷代谢及T淋巴细胞亚群的影响

中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (3): 231-233.

骨化三醇对腹透患者钙磷代谢及T淋巴细胞亚群的影响

蔡楚丹, 蔡聪, 卢娟娟, 卓乐莹, 钟卓衡, 周佩芳

汕头大学医学院第一附属医院肾脏内科, 汕头 515041

收稿日期:2002-02-19 修回日期:2002-03-13 发布日期:2020-12-01

Influence of calcitriol on calcium phosphorus metabolism and Tlympho-cyte subpopulation in peritoneal dialysis patients

CAI Chu-Dan, CAI Cong, LU Juan-Juan, ZHUO Yu-Yin, ZHENG Zhuo-Heng, ZHOU Pei-Fang

Department of Nephrology, the First Affiliated Hospital, Medical College of Shantou University, Shantou 515041

Received:2002-02-19 Revised:2002-03-13 Published:2020-12-01

摘要/Abstract

摘要： 目的: 了解骨化三醇(1, 25-(OH) 2D3, 罗钙全) 对腹膜透析患者钙磷代谢及免疫功能的影晌。方法: 观察37 例腹膜透析(PD) 患者服用骨化三醇前后血清T 细胞亚群、IL-8 以及血免疫反应甲状旁腺激素(iPTH) 、钙、磷水平变化。结果: 用药前 PD组血清T 淋巴亚群的 CD4/CD8 低于正常对照组(P<0.05), 服用骨化三醇 4 wk 后, CD4/CD8 从 0.56±0.10升至0.79±0.12;而 iPTH 显著降低, 血钙显著升高, 血磷明显下降。结论: 骨化三醇能改善PD患者钙磷代谢, 进而改善其免疫功能。

关键词: 腹膜透析, T 细胞亚群, IL-8, 骨化三醇

Abstract: AIM: To observe the influence of cal-citriol (1, 25-(OH) 2D3) on calcium phosphorus metabolism andimmunologic function of peritoneal dialy-sis (PD) patients.METHODS: The level of serum T cell subpopulation, IL-8, immunoreactive parathyroid hormone(iPTH), calcium, and phosphorus were observed before and after patients taking calcitriol.RESULTS: Before taking medicine, CD4/CD8 of group PD was lower than that of normal comparing group (P<0.05);4 weeks after taking calcitriol, CD4/CD8 rised from 0.56±0.10 to 0.79±0.12, andiPTH clearly reduces, while blood calcium, and blood phosphorus obviously goes down as well.CONCLUSION: Calcitriol is able to improve the calcium phosphorus metabolism of PD patients, and their immunologic function.

Key words: peritoneal dialysis, Tlymphocyte sub-groups, interleukin-2, calcitriol

中图分类号:

R969.4

蔡楚丹, 蔡聪, 卢娟娟, 卓乐莹, 钟卓衡, 周佩芳. 骨化三醇对腹透患者钙磷代谢及T淋巴细胞亚群的影响[J]. 中国临床药理学与治疗学, 2002, 7(3): 231-233.

CAI Chu-Dan, CAI Cong, LU Juan-Juan, ZHUO Yu-Yin, ZHENG Zhuo-Heng, ZHOU Pei-Fang. Influence of calcitriol on calcium phosphorus metabolism and Tlympho-cyte subpopulation in peritoneal dialysis patients[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2002, 7(3): 231-233.

[1]	赵艳花, 金玉婷, 王文林. 1例腹膜透析相关性腹膜炎的药学监护[J]. 中国临床药理学与治疗学, 2015, 20(7): 775-777.
[2]	张蔚青, 杨榕, 阙彬, 倪卫国, 徐珂, 刘胜强, 梁志鹏. 罗哌卡因腰麻对腹膜透析置管术患者炎症因子的影响[J]. 中国临床药理学与治疗学, 2013, 18(4): 404-407.
[3]	帅训军, 宫倩红, 艾登斌, 付世欧. 依达拉奉对单肺通气患者围术期细胞因子IL-6、IL-8及其mRNA表达的影响[J]. 中国临床药理学与治疗学, 2010, 15(3): 326-330.
[4]	颜雪琴, 吴立琴, 林洁, 夏晓东, 戴元荣. 罗红霉素与布地奈德干粉吸入剂联用治疗哮喘的临床研究[J]. 中国临床药理学与治疗学, 2008, 13(2): 184-187.
[5]	徐海红, 张苗, 蒋春明. 黄芪注射液对腹膜透析相关腹膜间皮细胞TGF-β₁分泌与表达的影响[J]. 中国临床药理学与治疗学, 2005, 10(7): 791-794.
[6]	张晓慧, 梁凤珍. 补肾活血法治疗慢性再生障碍性贫血疗效的临床评价[J]. 中国临床药理学与治疗学, 2004, 9(4): 423-425.
[7]	臧翠平, 叶任高, 阳晓. 糖尿病肾病尿毒症透析方法的探讨[J]. 中国临床药理学与治疗学, 2002, 7(4): 331-333.
[8]	张怡玲, 唐建吾, 董振波, 郭亚芳. 抗生素及抗凝药对小鼠腹膜影响实验研究[J]. 中国临床药理学与治疗学, 1999, 4(4): 279-281.