关键词: 地氟醚, 血液动力学, 组织型纤溶酶原激活物, 纤溶酶原激活物抑制物

Abstract: AIM: To investigate the effect of low concentration desflurane on hemodynamics and fibrinolysis in patients during general anesthesia.METHODS: Twenty-eight ASA grade Ⅰ-Ⅱ patients during general anesthesia, scheduled for elective chest surgery, were studied, and hemodynamics and fibrinolysis were observed after inhalation of desflurane at 0.5 and 1.0 MAC, re-spectively.RESULTS: Compared with those before anes-thesia, SBP, DBP, and MAP remarkably decreasedand HR significantly increased at intubation.However, the changes were more remarkable than those of before anes-thesia when inhalation of desflurane at 0.5 and 1.0 MAC;blood pressure did not further decreased;and HR did not increasedin comparison with intubation.The level of plasma tissue plasminogen activator (t-PA) re-markably increasedand the level of plasma plasminogen activitor inhibitor (PAI) significantly decreased when in-halation of desflurane.The level of plasma t-PA further increasedand the level of plasma PAI further decreased as inhalation of increased desflurane concentration.CONCLUSION: There are someeffects of low concentration desflurane on hemodynamics and fibrinolysis in patients with chest surgery during general anesthesia.

Key words: desflurane, hemodynamics, tissue plas-minogen activitor, plasminogen activitor inhibitor