欢迎访问《中国临床药理学与治疗学》杂志官方网站,今天是

中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (3): 245-247.

• 临床研究 • 上一篇    下一篇

培哚普利单用和与格列齐特联用治疗糖尿病肾病的临床疗效评价

张效东, 李新立, 刘群才   

  1. 解放军159 医院内科, 驻马店 463008
  • 收稿日期:2002-04-06 修回日期:2002-04-20 发布日期:2020-12-01

Clinical evaluation of the effect of perindopril alone and combined with gliclazide in the treatment of diabetic nephropaphy

ZHANG Xiao-Dong, LI Xin-Li, LIU Qun-Cai   

  1. Department of Internal Medicine, the 159th Hospital of PLA, Zhumadian 463008
  • Received:2002-04-06 Revised:2002-04-20 Published:2020-12-01

摘要: 目的: 评价培哚普利(perindopril) 单用和与格列齐特联用对治疗Ⅱ型糖尿病(DM) 伴高血压合并糖尿病肾病 (DN) 病人的疗效及安全性。方法: 61 例病人, 男34 例, 女27 例。随机分为两组, 培哚普利组31 例, 培哚普利 4 mg, 1 次/d;格列齐特 80 mg, 2次/d 。硝苯地平组30 例, 硝苯地平缓释片 10 mg, 1次/d;格列齐特 80 mg, 2 次/d 。以治疗 3 mon 为统计界限。结果: 两组治疗前后比较, 收缩压、舒张压、空腹血糖(FPG) 、糖化血红蛋白 (GHb) 明显降低(P<0.05), 培哚普利组尿微量白蛋白(UMA) 显著下降(P<0.01), 硝苯地平组 UMA 无明显变化(P > 0.05) 。两组治疗后, 收缩压、舒张压、空腹血糖(PLG) 、糖化血红蛋白(GHb) 比较无显著性差异(P>0.05) 。培哚普利组尿微量蛋白(UMA) 较硝苯地平组明显下降(P<0.01) 。两组治疗前后及治疗后比较, WBC 、RBC 、PLT 、血清尿素、Cr 及 K+ 均无明显变化(P >0.05) 。结论: 培哚普利是治疗Ⅱ型DM 伴高血压合并 DN 保护肾功能安全有效的药物;培哚普利和格列齐特联合应用效果更佳。

关键词: Ⅱ型糖尿病, 糖尿病肾病, 培哚普利, 尿微量白蛋白

Abstract: AIM: To observed clinical effect and safety of perindopril alone and combined with gliclazide in the treatment of type Ⅱdiabetic with hypertension and di-abetic nephropaphy (DN).METHODS: 61 patients (male 34, female 27) were randomly dividedinto 2 groups. Perindopril group (n =31):perindopril 4 mg qd, and gliclazide 80 mg bid.Nifedipine group (n = 30):nifedipine 10 mg qd, and gliclazide 80 mg bid.The treatments lasted for three months.RESULTS: After the treatments, the levels of blood pressure, FPG, and GHb were distinctly reducedin the two groups (P<0.05), but the marked differences did not show between the two groups (P >0.05).In perindopril group, the urine min-im albumin (UMA) was markedly reduced (P<0.01), but nifedipine group was not changed.The values of + WBC, RBC, PLT, Ure, Cr and K in the two groups were not changed before and after the treatments.CONCLUSION: Perindopril is safe and effective in the treat-ment of the type Ⅱdiabetic with hypertension and diabetic nephropaphy.The agent can obtain a better effect in com-bination with gliclazide than alone.

Key words: nephropaphy, nifedipine, perindopril, urine minim albumin

中图分类号: