碱性成纤维细胞生长因子复合制剂局部治疗复发性阿弗他溃疡的临床研究

中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (3): 248-249.

碱性成纤维细胞生长因子复合制剂局部治疗复发性阿弗他溃疡的临床研究

宋薇

皖南医学院弋矶山医院口腔科, 芜湖 241001

收稿日期:2002-02-21 修回日期:2002-04-10 发布日期:2020-12-01
作者简介:宋薇, 联系作者, 女, 主治医师。Tel:0553-5738856-2337

Clinical study of compound bFGF preparations on patients with recurrent aphthous ulcer

SONG Wei

Department of Stomatology, Yijishan Hospital, Wannan Medical College, Wuhu 241001

Received:2002-02-21 Revised:2002-04-10 Published:2020-12-01

摘要/Abstract

摘要： 目的: 观察bFGF复合制剂局部治疗复发性阿弗他溃疡的近期疗效。方法: bFGF 组 60 例应用bFGF 与适量替硝唑、地卡因配伍成复合制剂喷涂于溃疡面;常规治疗组40 例应用锡类散、思密达交替涂敷于溃疡面, 均每日 3 次, 疗程 5 d 。结果: bFGF组溃疡大小、疼痛及充血 3 项指标改善值均明显优于对照组(P<0.001), 临床疗效较常规治疗组显著(P<0.05) 。无明显不良反应。结论: 该复合制剂局部治疗复发性阿弗他溃疡安全、有效。

关键词: 碱性成纤维细胞生长因子, 替硝唑, 地卡因, 阿弗他溃疡

Abstract: AIM: To observe the recent curative ef-fect of basic fibroblast growth factor (bFGF) to patients with recurrent aphthous ulcer (RAU).METHODS: 60 patients with RAU were treated by locally spraying com-pound bFGF preparations composing of calculated quantity of bFGF, tinidazole and dicaine on the surface of ulcera-tions, other 40 patientswere treated by alternatively smear-ing Xi Leisan and Smecta on the surface of ulcerations as routine treatment group, tid, for 5 d.RESULTS: The improvement of three indexes including the size, the de-gree of ache and hyperemia of the ulcerations are greater in compound bFGF treatment group than those in routine treatment group (P<0.001), and the effectiverate was also higher in bFGF treatment group (86.67 %) than those in (65.00 %) routine treatment group (P<0.05). No significant side effect was observed during the treat-ment with compound bFGF.CONCLUSION: The com-pound bFGF preparations usedin this study is effective and safe for the treatment of RAU.

Key words: basic fibroblast growth factor, tinida-zole, dicaine, aphthous ulcer

中图分类号:

R969.4

宋薇. 碱性成纤维细胞生长因子复合制剂局部治疗复发性阿弗他溃疡的临床研究[J]. 中国临床药理学与治疗学, 2002, 7(3): 248-249.

SONG Wei. Clinical study of compound bFGF preparations on patients with recurrent aphthous ulcer[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2002, 7(3): 248-249.

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