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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (3): 279-282.

• 综述与讲座 • 上一篇    下一篇

抗癫痫新药托吡酯药代动力学研究现状1

和喜梅, 何欣, 张二淮   

  1. 郑州大学医学院医学实验中心, 郑州 450052
  • 收稿日期:2001-12-28 修回日期:2002-03-08 发布日期:2020-12-01
  • 基金资助:
    1 本课题为河南省卫生厅资助项目(No91018)

Advances of pharmacokinetic studies of topiramate, a new antiepileptic a-gent

HE Xi-Mei, HE Xin, ZHANG Er-Huai   

  1. Medical Laboratory Center, School of Medicine, Zhengzhou University, Zhengzhou 450052
  • Received:2001-12-28 Revised:2002-03-08 Published:2020-12-01

摘要: 本文综述了抗癫痫新药托吡酯近年来药代动力学的研究现状。从单剂量、多剂量以及与其它药物联合应用时药动学参数的确定, 到各种因素如年龄、疾病等影响下药动学参数的改变, 揭示出该药在正常人体及病态下体内代谢、排泄的规律, 为我国癫痫病患者临床合理用药提供参考资料。

关键词: 托吡酯, 癫痫, 药代动力学

Abstract: The article introduced advances of pharma-cokinetic studies of topiramate, a new antiepileptic agent, in recent years.Topiramate pharmacokinetic parameters were determined after the administrations of single dose, multiple dose and concomitant therapy.The changes of its pharmacokinetic parameters were determinedin the influ-ence of the factors, for example, age, disease, and so on.These results haverevealed the regulations of metabolism and excretion of topiramate in the healthy vol-unteers and patients.The data provide a basis of clinical rational medication for the patiens with epilepsy. KEY WORDS:topiramate;epilepsy;pharmacokinetics

Key words: topiramate, epilepsy, pharmacokinetics

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