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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (4): 293-295.

• 基础研究 • 上一篇    下一篇

特种红曲对鹌鹑实验性脂肪肝的治疗作用

王银叶, 韦薇, 李长龄   

  1. 北京大学药学院药理学系, 北京 100083
  • 收稿日期:2002-04-05 修回日期:2002-05-18 出版日期:2002-08-26 发布日期:2020-11-24
  • 通讯作者: 李长龄, 男, 教授, 系主任, 博士生导师。主要研究方向:心血管药理学及神经药理学。
  • 作者简介:王银叶, 女, 副教授, 硕士生导师。Tel:010-62092652 Email:wangyinye@bjmu. edu. cn

Effect of monascus purpureus fermented rice on fatty liver in quails

WANG Yin-Ye, WEI Wei, LI Chang-Ling   

  1. Depastment of Pharmacology, School of Pharmaceutical Sciences, Beijing University, Beijing 100083
  • Received:2002-04-05 Revised:2002-05-18 Online:2002-08-26 Published:2020-11-24

摘要: 目的: 观察特种红曲对鹌鹑实验性脂肪肝的影响, 以确证其治疗效果。方法: 建立乙醇性脂肪肝鹌鹑模型, 测定给药前后的血脂和肝脂水平, 并进行肝脏病理组织学检查。结果: 特种红曲1. 6 g·kg-1 给脂肪肝鹌鹑灌胃20 d, 可明显降低血浆总胆固醇(TC), 甘油三酯( TG) 和低密度脂蛋白( LDL) 水平( P<0. 01), 同时降低肝脏TC 和TG 水平( P <0. 01); 特种红曲0. 8 g·kg-1 也可降低血浆TC 和LDL 水平( P <0. 05) 和肝脏TC 水平( P <0. 01), 并可使肝组织的脂变程度明显减轻, 部分动物的肝脏甚至完全恢复正常。结论: 特种红曲对实验性脂肪肝具有治疗作用。

关键词: 特种红曲, 血脂, 脂肪肝, 鹌鹑

Abstract: AIM: To investigate the effect of monascus purpureus fermented rice ( MR) on alcohol-fatty liver model in quails. METHODS: A fatty liver model was established in quails, then the lipid levels of the models were tested in both plasma and liver, and the examination in the pathological-histology of liver was conducted. RESULTS: 1. 6 g·kg-1·d-1 of MR given orally for 20 d significantly decreased TC, TG and LDL ( P < 0. 01) in serum, and TC, TG in liver of quails. 0. 8 g· kg-1·d-1 of MPFR also decreased TC and LDL in serum ( P <0. 05) and TC in liver ( P <0. 01). MR lowered the rate of liver fatty degeneration with a dose-dependent manner and reduced the degree of liver fatty degeneration. CONCLUTION: MR shows a therapeutic efficacy on alcoholic fatty liver model in quails, suggesting that it may be used as a kind drug or a kind of health food in prevention or treatment of patients with fatty liver.

Key words: monascus rice, blood lipid, fatty liver

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