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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (4): 299-301.

• 基础研究 • 上一篇    下一篇

人参茎叶皂甙对5-氟脲嘧啶抗肿瘤的增强作用

陈方, 吴铁, 傅玉萍, 刘晓青   

  1. 广东医学院药药理教研室, 湛江 524023
  • 收稿日期:2002-04-29 修回日期:2002-05-29 出版日期:2002-08-26 发布日期:2020-11-24
  • 通讯作者: 陈方, 男, 讲师, 在读硕士生, 主要从事抗肿瘤药和抗糖尿病药研究。Tel:0759-2388588 E-mai l:gdmc. cf@163. com
  • 作者简介:吴铁, 男, 副教授, 硕士生导师, 主要从事抗肿瘤药、抗糖尿病药和抗骨质疏松药研究。E-mail:wutie @gdmc.edu. cn

Enhancement of ginsen-stem-leaves to the antitumor effect of 5-FU in mice inoculated S180

CHEN Fang, WU Tie, FU Yu-Ping, LIU Xiao-Qing   

  1. Department of Pharmacology, Guangdong Medical College, Zhanjiang 524023
  • Received:2002-04-29 Revised:2002-05-29 Online:2002-08-26 Published:2020-11-24

摘要: 目的: 观察人参茎叶皂甙(GSL) 促进氟脲嘧啶( 5-FU) 对小鼠S180 实体瘤的抑瘤作用。方法: 采用昆明种小鼠, 随机分组进行实验, 分别给予不同剂量人参茎叶皂甙与氟脲嘧啶配伍使用, 观察其对小鼠S180 实体瘤抑瘤率的差别。结果: 低剂量人参茎叶皂甙( 15 mg·kg-1) 与氟脲嘧啶( 1. 5 mg·kg-1) 组方对小鼠S180 实体瘤有显著的抑瘤作用( 抑瘤率达26. 90 %, P <0. 05), 对胸腺无抑制作用;阳性对照药5-FU( 25 mg·kg-1) 的抑瘤率为36. 61 %, 但其对胸腺有显著抑制作用;而人参茎叶皂甙( 100 mg·kg-1) 单用对小鼠S180 实体瘤抑瘤率为27. 44 %。结论: 低剂量人参茎叶皂甙( 15 mg·kg-1) 显著促进5-FU( 1. 5mg·kg-1) 对小鼠S180 实体瘤的抑瘤作用而无胸腺抑制作用, 可并减少5-FU 的毒副作用。

关键词: 人参茎叶皂甙, 5-FU, S180, 抗瘤作用

Abstract: AIM: To observe the enhancement of ginsen-stem-leaves (GSL) to the antitumor effect of 5-FU in mice inoculated S180. METHODS: The different combinations of GSL and 5-FU were used to examine the inhibition rates of tumor growth in KM mice inoculated S180. RESULTS: The combination of GSL ( 15 mg·kg-1) and 5-FU ( 1. 5 mg·kg-1) obtained 26. 90 % of inhibition rates of tumor growth ( P <0. 05), and did not inhibit the thymus. The antitumor rate of 5-FU ( 25 mg·kg-1) was 36. 61 %, and the dose markedly decreased the weight of thymus. CONCLUSION: The combination of GSL ( 15 mg·kg-1) and 5-FU ( 1. 5mg·kg-1) can markedly inhibit the tumor growth of S180 inmice, but does not decrease the weight of thymus, suggesting that the combination may decrease the side effect produced by 5-FU.

Key words: ginsen-stem-leaves ( GSL ), 5-FU, S180, antitumor effect

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