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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (4): 314-316.

• 基础研究 • 上一篇    下一篇

薄荷醇对环丙沙星粘膜吸收的影响1

赵怀军, 王晖1, 冯建青, 黄金水   

  1. 湛江出入境检验检疫局, 湛江 524001;
    1广东医学院药理学教研室, 湛江 524023
  • 收稿日期:2002-04-23 修回日期:2002-05-11 出版日期:2002-08-26 发布日期:2020-11-24
  • 通讯作者: 赵怀军, 男, 在读研究生, 主治医师, 主要从事口腔疾病临床研究。Tel:0759-2229974 Emai l:gdmcdwzx @gdmc.edu. cn
  • 作者简介:王晖, 男, 副教授, 硕士, 硕士生导师, 广东省“ 千百十工程” 院级重点培养对象。研究方向为皮肤粘膜药理学和定量药理学。黄金水, 男, 主任医师, 副局长, 主要研究方向为传染病监测。
  • 基金资助:
    1 国家出入境检验检疫局资助课题(№GDK02-2001)

Effect of l-menthol on mucosa absorption of ciprofloxacin

ZHAO Huai-Jun, WANG Hui1, FENG Jian-Qing, HUANG Jin-Shui   

  1. Zhanjiang Entry-exit Inspection and Quarantine Bureau, Zhanjiang 524001;
    1Department of Pharmacology, Guangdong Medical College, Zhanjiang 524023
  • Received:2002-04-23 Revised:2002-05-11 Online:2002-08-26 Published:2020-11-24

摘要: 目的: 探讨薄荷醇对环丙沙星粘膜吸收的影响。方法: 在双室透皮扩散装置上进行体外透粘膜吸收试验, 计算渗透系数。结果: 环丙沙星的粘膜吸收随着浓度的增加, 渗透系数有逐渐增加的趋势, 而贮库效应降低更明显;使用薄荷醇后, 环丙沙星的渗透系数均表现为下降趋势, 尤其是0. 2 %浓度薄荷醇组下降作用最明显(P <0. 01), 但其贮库效应却明显强于其它组。结论: 薄荷醇可明显降低环丙沙星粘膜吸收的渗透系数, 加强其贮库效应。

关键词: 薄荷醇, 环丙沙星, 粘膜吸收, 渗透系数, 贮库效应

Abstract: AIM: To investigate the effect of l-menthol on the absorption of ciprofloxacin (Cip)via the mucosa. METHODS: Mucosa absorption experiment and deposit effect were made on a two-cells diffusion apparatus in vitro to calculate permeation coefficients. RESULTS: With increasing of the concentration of Cip, the permeation coefficient of mucosa absorption showed a increasing tendency, but deposit effect declined significantly. After using l-menthol, the permeation coefficient of Cip showed a declining tendency. Especially at 0. 2 percent concentration of l-menthol, the decrease level was more obvious than other groups (P <0. 01), but its deposit effect was the largest. CONCLUSION: L-Menthol could decrease permeation coefficient of mucosa absorption of Cip and obviously enhance deposit effect of Cip.

Key words: l-menthol, ciprofloxacin, mucosa absorption, permeation coefficient, deposit effect

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