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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (4): 324-326.

• 临床研究 • 上一篇    下一篇

伊贝沙坦对原发性高血压的疗效及心率变异性的影响

原芳, 杜松, 王留义, 王丽霞   

  1. 河南省人民医院心内科, 郑州 450003
  • 收稿日期:2002-04-07 修回日期:2002-05-10 出版日期:2002-08-26 发布日期:2020-11-24
  • 通讯作者: 原芳, 女, 硕士, 主治医师, 从事动脉粥样硬化疾病的研究。Tel:0371-5580669 E-mai l:xy @gf.com. cn
  • 作者简介:王留义, 男, 博士, 副主任医师, 从事心率变异和基因治疗的研究。

Effects of irbesartan on blood pressure and heart rate variability in patients with essential hypertension

YUAN Fang, DU Song, WANG Liu-Yi, WANG Li-Xia   

  1. Department of Cardiology, Henan Provincial People' s Hospital, Zhengzhou 450003
  • Received:2002-04-07 Revised:2002-05-10 Online:2002-08-26 Published:2020-11-24

摘要: 目的: 观察伊贝沙坦对原发性高血压( EH) 的疗效及心率变异性的变化。方法: 原发性高血压患者40 例每日口服伊贝沙坦150 ~ 300 mg, 共8 wk 。观察血压变化, 记录用药前后24 h 动态心电图, 分析心率变异( HRV) 时域和频域指标, 并与35 例健康对照组比较。结果: ①EH 患者应用伊贝沙坦后收缩压( SBP) 和舒张压( DBP) 由21. 62 ±0. 47/12. 01 ± 0. 32 kPa 分别下降至18. 9 ±0. 32/8. 01 ±2. 35 kPa,有效率达73. 1 %。②与对照组相比, EH 患者相邻正常RR 间期标准差( SDNN), 正常相邻RR 间期差值( RMSSD), 相邻正常RR 间期差值大于50 ms 的窦性心律( PNN50), 高频功率( HF) 明显下降, 低频功率( LF) 不变, 低频功率/高频功率( LF/HF) 值增加。应用伊贝沙坦后, SDNN 、RMSSD 、PNN50 、HF 增加, LF/HF 值降低。结论: 原发性高血压患者存在HRV 下降, 而伊贝沙坦在有效降低血压同时提高HRV, 改善自主神经功能失衡。

关键词: 伊贝沙坦, 原发性高血压, 心率变异性

Abstract: AIM: To study the effects of irbesartan on blood pressure and heart rate variability ( HRV) in patients with essential hypertension ( EH). METHODS: 40 patients with EH received 150-300 mg·d-1 irbesartan for 8 weeks. The changes in blood pressure were assessed. The time-and frequency-domain measurements of HRV from 24 hours ambulartory electrocardiographyic recordings were analyzed in 35 healthy controls and in patients with EH before and after the treatment. RESULTS: Compared to baseline, the systolic and diastolic blood pressure decreased from 21. 62 ±0. 47/12. 01 ± 0. 32 kPa to 18. 90 ±0. 32/8. 01 ±2. 35 kPa in the irbesartan groups, and respond rates were 73. 1 %.Compared with controls, the standard deviation of normal-to-normal intervals (SDNN), rate-mean-square of the differences of successive RR intervals ( RMSSD), the percentage of RR intervals differing >50 ms ( PNN50 ) and the high frequency ( HF) in patients with EH were decreased, While the ratio between low frequency and high frequency ( LF/ HF) were increased. After the treatment of irbesartan, the values of SDNN, RMSSD, PNN50, and HF were increased, and the LF/HF was decreased significantly. CONCLUSION: Irbersartan can increase the lowed HRV in patients with EH, which improves the cardiovascular automatic function.

Key words: irbesartan, essential hypertension, heart rate variability

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