西布曲明对不同肥胖者的减重作用

中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (4): 327-330.

西布曲明对不同肥胖者的减重作用

王绘, 陈斌

江苏省盐城市城区人民医院内科, 盐城 224001

收稿日期:2001-12-29 修回日期:2002-05-25 出版日期:2002-08-26 发布日期:2020-11-24
通讯作者: 王绘, 女, 副主任医师。从事肥胖相关疾病的临床治疗。Tel:0515-8322036 E-mai l:wvrs @sina.com

Weight relief of sibutramine in treatment of obesity with different body weight

WANG Hui, CHEN Bing

Department of Internal Medicine, Yancheng Hospital, Yancheng, Jiangsu 224001

Received:2001-12-29 Revised:2002-05-25 Online:2002-08-26 Published:2020-11-24

摘要/Abstract

摘要： 目的: 观察盐酸西布曲明在不同体重病人中的减重作用。方法: 40 名肥胖患者, 根据体重指数( BMI) 分组:肥胖早期组( n =10) 、Ⅰ 度肥胖组( n = 11) 、Ⅱ度肥胖组( n =19), 40 名患者都给予饮食、体育活动和生活方式的改变标准化, 在此基础上给予盐酸西布曲明10 mg·d^-1, 治疗期12 wk 。结果: 3 组病人体重均有不同程度的下降, 服药2 wk 后Ⅰ度肥胖组有效5 例( 45. 5 %), Ⅱ 度肥胖组有效18 例( 94. 7 %) ( P <0. 01); 服药4 wk, Ⅰ 度肥胖组有效9例( 81. 8 %), 显效1 例( 9. 1 %), Ⅱ 度肥胖组有效3例( 5. 8 %), 显效16 例( 84. 2 %) ( P <0. 01); 服药12 wk, 肥胖早期组始出现5 例有效( 55. 6 %), Ⅰ 度肥胖组有效4 例( 36. 4 %), 显效7 例( 63. 6 %), Ⅱ度肥胖组显效19 例( 100 %) ( P <0. 01) 。结论: 盐酸西布曲明是一安全有效的减肥药, 并随体重的不同疗效不一, 疗效与基础体重成正比。

关键词: 西布曲明, 体重指数, 肥胖症

Abstract: AIM: To observe the effect of sibutramine in the treatment of obesity with different body weight. METHODS: Forty overweight subjects were divided into three groups according to their BMI: Group 1 ( n =10), the early stage of obesity; Group 2 ( n =11), obesity in degree Ⅰ; and Group 3 ( n =19), obesity in degree Ⅱ. The patients conformed to the same standards of diet, sports and life style, and then took sibutramine 10 mg a day for 12 weeks. RESULTS: After taking the medicine for two weeks, the efficacy rate was 45. 5 %( 5) in Group 2 and 94. 7 % ( 18) in Group 3 ( P <0. 01); four weeks later, 81. 8 % ( 9) in Group 2 and 5. 8 % ( 3) in Group 3; the obvious effect rate was 9. 1 % ( 1) in Group 2 and 84. 2 % ( 16) in Group 3 ( P <0. 01). After 12 weeks, the efficacy rate was 55. 6 % ( 5) in Group 1, 36. 4 % ( 4) in Group 2; the obvious effect rate was 63. 6 % ( 7) in Group 2 and 100 % ( 19) in Group 3 ( P <0. 01). CONCLUSION: Sibutramine is safe and efficient in the treatment of obesity with different body weight. The effect increases with body weight increasing.

Key words: sibutramine, BMI, obesity

中图分类号:

R969.4

王绘, 陈斌. 西布曲明对不同肥胖者的减重作用[J]. 中国临床药理学与治疗学, 2002, 7(4): 327-330.

WANG Hui, CHEN Bing. Weight relief of sibutramine in treatment of obesity with different body weight[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2002, 7(4): 327-330.

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