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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (6): 529-531.

• 研究原著 • 上一篇    下一篇

L-精氨酸对应激性大鼠血压的影响1

尹艳茹, 柏林   

  1. 第一军医大学分校生理学教研室,广州 510315
  • 收稿日期:2002-09-17 修回日期:2002-09-28 出版日期:2002-12-26 发布日期:2020-11-20
  • 通讯作者: 尹艳茹,女,副教授。Tel:08219935-50511  Email:yyr6454@163.com
  • 基金资助:
    1 广东省医学科学技术研究基金资助项目(A1999482)

Effect of L-arginine on blood pressure in stress rats

YIN Yan-Ru, BAI Lin   

  1. Department of Physiology,Branch Campus of the First Military Medical University,Guangzhou 510315
  • Received:2002-09-17 Revised:2002-09-28 Online:2002-12-26 Published:2020-11-20

摘要: 目的 研究L-精氨酸(L-ARG)对应激性大鼠血压(BP)的影响。方法 给SD 大鼠的饮水中添加L-ARG,并给予间断性足底电刺激15 d,隔日监测尾动脉BP 1 次,观察其尾动脉BP 的变化情况和血浆一氧化氮(NO)浓度变化。并与单纯应激组和正常对照组比较。结果 单纯应激组在d 9 、d 11 、d 13 、d15,BP 升高,与正常对照组相比,差异有显著的统计学意义(P <0.05或P <0.01);血中NO 的浓度低于正常对照组(P <0.05)。L-ARG+应激组隔日测得BP 与对照组相比,其差异无统计学意义,d 15 BP 低于正常对照组(P <0.05),BP 呈下降趋势,NO 明显升高(P <0.01)。结论 L-ARG 有阻抑应激性大鼠BP 升高的作用。

关键词: L-精氨酸, 应激, 血压

Abstract: AIM: To observe the effect of L-arginine on blood pressure(BP)in stress rats.METHODS: Thirty rats were divided into three groups.L-ARG +stress group:L-arginine was added in drinking-water and electric stimulus were given intermittently in rat foot-plate for 15 days;stress group:electric stimulus was given as above;control group:no stress.The Bplevels of tail artery were measured per two days,and the concentrations of nitric oxide(NO)of plasma were detected on 15th day.RESULTS: There were significantly differences on Bpbetween control groupand stress groupin the 9th,11th,13th,15th day(p<0.05 or p<0.01).After the stimulus in the stress group,the level of Bpincreased,the concentration of NO decreased(p<0.05).However,the Bpdid not show obvious difference between control groupand L-ARG +stress group.On the 15 th day,the Bplevel decreased in L-ARG +stress group(p<0.05),and the concentration of NO was higher than that of control group(p<0.01).CONCLUSION: L-ARG can resist the increase of Bpin stress rats.

Key words: L-arginine, stress, BP

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