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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (6): 557-558.

• 研究原著 • 上一篇    下一篇

卡介苗素对支气管哮喘患者免疫调节作用

刘乾中, 周世良1   

  1. 江西省肺科医院呼吸科,南昌 330006;
    1江西医学院影像系,南昌 330006
  • 收稿日期:2002-07-17 修回日期:2002-07-24 出版日期:2002-12-26 发布日期:2020-11-20
  • 通讯作者: 刘乾中,男,硕士,主治医师。Tel:0791-6775619

Immunologic effect of extra bacillus calmette guerin on asthmatic patients

LIU Qian-Zhong, ZHOU Shi-Liang1   

  1. Department of Respiration,Jiangxi Provincial Pneumoloy Hospital; Department of Screenage,Jiangxi Medical College,Nanchang 330006
  • Received:2002-07-17 Revised:2002-07-24 Online:2002-12-26 Published:2020-11-20

摘要: 目的 探讨卡介苗素对哮喘患者免疫调节作用。方法 58 例发作期的哮喘病人,观察组34 例,对照组24 例,入组前行血浆IL-14 、IL-12 水平测定。观察组:吸入普米克气雾剂,其用量参照哮喘阶梯治疗方案,可加用解痉剂(不包括茶碱类),卡介苗素0.5 mg 肌注,每周2 次。对照组:除不用卡介苗素外余同观察组。3 mon 后所有病例复查血浆IL-4 、IL-12 水平。结果 治疗后观察组血浆IL-4 水平由治疗前(29.0±5.6)降至(22.6±6.5)ng·L-1;IL-12 水平由治疗前(37.2±4.6)增至(51.7±10.7)ng·L-1,均有显著性差异(P <0.05)。对照组血浆IL-4水平由治疗前(29.7±5.1)降至(26.4±4.9)ng·L-1,有显著性差异(P <0.05);IL-12 水平由治疗前(38.1±6.7)升至(39.3±7.8)ng·L-1,但差异无显著性意义(P >0.05)。治疗后复查IL-4 、IL-12 水平,两组间相比差异有显著性意义(P <0.05)。结论 卡介苗素可抑制Th2 型细胞因子IL-4 分泌,促进Th1型细胞因子IL-12 的分泌,从而调节Th1/Th2 平衡,对哮喘患者有明显的免疫调节作用。

关键词: 卡介苗素, 支气管哮喘, 白介素-4, 白介素-12

Abstract: AIM: To explore the immunologic effect of extra bacillus calmette guerin(EBCG)on asthmatic patients.METHODS: 58 asthmatic patients in acute exacerbation were randomly enrolled into two groups:EBCG group(n=34)and control group(n=24).Before treatment,the levels of interleukin-4(IL-4)and interleukin-12(IL-12)in blood plasma were examined in both groups.The patients in EBCG groupinhaled budesonide aerosol according to asthmatic ladder treatment program and injected with EBCG.Spasmolytic could be used if necessary(excluding theophylline).The patients in control grouponly used budesonide aerosol and spasmolytic.The level of IL-4 and IL-12 in blood plasma were determined again after three months.RESULTS: After the drug intervention,the level of IL-4 significantly decreased in EBCG group(29.0±5.6 vs 22.6±6.5 ng·L-1,P<0.05),but IL-12 concentrations in plasma markedly increased(37.2±4.6 vs 51.7±10.7 ng ·L-1,p<0.05).In control group,the level of IL-4 decreased from(29.7±5.1)to(26.4±4.9)ng·L-1(p<0.05),but IL-12 concentrations did not significantly change(p>0.05).Before drug intervention,no significant differences were found between two groups in IL-4 and IL-12concentrations;However,there were markedly differences after drug intervention(p<0.05).CONCLUSION: EBCG can restrain the secretion of IL-4 and contribute to the secretion of IL-12 in asthmatic patients.

Key words: extra bacillus calmette guerin, asthma, interleukin-4, interleukin-12

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