高血糖与糖尿病肾病

中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (6): 565-569.

高血糖与糖尿病肾病

谭正怀, 沈映君¹

四川省中药研究所,成都 610041;
¹成都中医药大学,成都 610072

收稿日期:2002-07-01 修回日期:2002-07-29 出版日期:2002-12-26 发布日期:2020-11-20
通讯作者: 谭正怀,男,副主任药师,博士生,主要从事药理学研究。Tel:028-85258982 　Fax:028-85224504 　E-mail:tanzhh616@sohu.com
作者简介:沈映君,教授,博士生导师,国家药品审评专家,中国药理学会中药药理专业委员会委员。

High glucose and diabetic nephropathy

TAN Zheng-Huai, SHEN Ying-Jun¹

Sichuan Institute of Chinese Materia Medica,Chengdu 610041;
¹Chengdu University of Tradition Chinese Medicine,Chengdu 610072

Received:2002-07-01 Revised:2002-07-29 Online:2002-12-26 Published:2020-11-20

摘要/Abstract

摘要： 糖尿病肾病(diabetic nephropathy,DN)是糖尿病的一种严重的微血管并发症,是目前引起糖尿病患者死亡的主要原因之一。其发病机理至今未明,由于血糖升高是糖尿病的主要临床表现,因此高血糖与糖尿病肾病的关系引起了广泛的重视。近年的研究资料表明,高血糖既可直接对肾脏组织造成损害,又可通过促进非酶促糖基反应、活化多元醇代谢途径、增加氧化应激、降低基质蛋白的降解等途径,使肾组织受损,最终导致DN 的形成。

关键词: 高血糖, 糖尿病肾病, 醛糖还原酶, 氧化应激, 基质金属蛋白酶

Abstract: Diabetic nephropathy is a sever microvascular complication of diabetes mellitus.Through the pathogenesis of diabetic nephropathy is unclear,the main manifestation of diabetes mellitus is the high level of blood glucose,andmore attention is paid to the relationshipbetween high glucose and diabetic nephropathy.It has been found in recent years that the tissues of kidney can be injured directly by high glucose,and also by producing over advanced glycation endproducts which activate the polyol pathway,increasing oxidative stress,and decreasing the activation of matrix matallo-proteinases.

Key words: high glucose, diabetic nephropathy, aldose reductase, oxidative stress, matrix matallo-proteinases

中图分类号:

R589.1

谭正怀, 沈映君¹. 高血糖与糖尿病肾病[J]. 中国临床药理学与治疗学, 2002, 7(6): 565-569.

TAN Zheng-Huai, SHEN Ying-Jun. High glucose and diabetic nephropathy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2002, 7(6): 565-569.

参考文献

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