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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (6): 570-573.

• 综述与讲座 • 上一篇    下一篇

骨质疏松动物模型的研究进展

刘钰瑜 综述, 吴铁, 王晖 审校   

  1. 广东医学院药理教研室,湛江 524023
  • 收稿日期:2002-08-26 修回日期:2002-09-04 出版日期:2002-12-26 发布日期:2020-11-20

Progress in animal models of experimental osteoporsis

LIU Yu-Yu, WU Tie, WANG Hui   

  1. Department of Pharmacology,Guangdong Medical College,Zhanjiang 524023
  • Received:2002-08-26 Revised:2002-09-04 Online:2002-12-26 Published:2020-11-20

摘要: 近年常用于骨质疏松的模型动物有大鼠、小鼠、兔、犬、羊、猪等。以大鼠最为常用。用于制模的方法有年龄相关的骨丢失,去势模型,药物类模型,废用性骨质疏松模型,营养类模型等。其中以去势模型,特别是去卵巢动物模型最常用。常用的评价方法有生化指标的测量、骨密度测量、骨组织计量学观察、骨生物力学指标检测等。其中生化指标和骨组织计量学是主要的指标。

关键词: 骨质疏松, 动物模型,

Abstract: Animals for model of osteoporosis involve rat,mouse,rabbit,beagle dog,minipig,sheep,etc.The types of model include aged-related model,ovariectomized model,orchietomied model,drug-treated model,abolition-degeneration model,and dietary-bone loss.The rat with ovariectomized model is used widely.Biochemical determination,bone mineral density measurement,bone histomorphorphormetry and bone biomechanics are used to judge the formation of experimental osteoporosis.

Key words: osteoporosis, animal model, bone

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