抗乙型肝炎病毒基因治疗的若干进展

中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (6): 574-576.

• 综述与讲座 • 上一篇

抗乙型肝炎病毒基因治疗的若干进展

余永胜, 陈有华¹

上海市第六人民医院传染科,上海 200233;
¹皖南医学院弋矶山医院传染科,芜湖 241001

收稿日期:2001-07-25 修回日期:2001-08-08 出版日期:2002-12-26 发布日期:2020-11-20
通讯作者: 余永胜,男,主治医师,从事感染性疾病的临床、科研工作。Tel:021-64369181-8670

Recent advances in genetic therapy for anti-hepatitis B virus

YU Yong-Sheng, CHEN You-Hua

Shanghai Sixth People' s Hospital,Shanghai 200233;
¹Department of Infectious Diseases,Affliated Yijishan Hospital,Wannan Medcal College,Wuhu 241001

Received:2001-07-25 Revised:2001-08-08 Online:2002-12-26 Published:2020-11-20

摘要/Abstract

摘要： 随着分子生物学特别是基因工程技术的发展,抗乙型肝炎病毒基因治疗有较深入的研究,利用基因重组、转基因及反义核酸等技术,在细胞水平或通过动物实验阶段的研究,基因有关治疗在抗乙肝病毒、抑制乙肝病毒复制中的作用已被证实。本文对转基因干扰素、DNA 疫苗(DNA 免疫)、反义寡核苷酸、三螺旋形成寡核苷酸(反基因寡核苷酸)、核酶有关抗乙型肝炎病毒基因治疗的研究进行综述。

关键词: 乙型肝炎转基因干扰素, DNA疫苗, 反义寡核苷酸, 三螺旋形成寡核苷酸, 核酶

Abstract: With the development of molecular biology,especially gene engineering technique,genetic therapy for anti-hepatitis B virus was deeply researched.Employing techniques of gene recombinant,transgene,and anti-sense nucleic acid etc,the function of genetic therapy for anti-hepatitis B virus was verified in cellular level or through animal experiment.In this article,studies on gene trangenically IFN,DNA vaccine(DNA immunization),antisense oligodeoxynucleotide(ONas),triple helix forming oligodeoxynucleotide(TFO),anti-gene oligodeoxynucleotide(ONan),ribozyme were reviewed.

Key words: heptitis B, gene trangenically IFN, DNA vaccine, antisense oligodeoxynucleotide(ONas), triple helix forming oligodeoxynucleotide(TFO), ribozyme

中图分类号:

R512.62

余永胜, 陈有华¹. 抗乙型肝炎病毒基因治疗的若干进展[J]. 中国临床药理学与治疗学, 2002, 7(6): 574-576.

YU Yong-Sheng, CHEN You-Hua. Recent advances in genetic therapy for anti-hepatitis B virus[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2002, 7(6): 574-576.

参考文献

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抗乙型肝炎病毒基因治疗的若干进展

Recent advances in genetic therapy for anti-hepatitis B virus

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