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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (2): 189-191.

• 研究原著 • 上一篇    下一篇

阿克他利治疗类风湿关节炎的有效性和安全性评价

厉小梅, 李向培, 汪国生, 单曙光, 钱龙   

  1. 安徽省立医院风湿科, 合肥 230001, 安徽
  • 收稿日期:2002-08-31 修回日期:2002-12-05 出版日期:2003-04-26 发布日期:2020-11-25
  • 通讯作者: 厉小梅, 女, 副主任医生, 主要从事风湿病研究。Tel:0551-2652797-3475 E-mail:jiaqk@USTC.edu.cn

Effectiveness and safety of actarit in the treatment of patients with active rheumatoid arthritis

LI Xiao-Mei, LI Xiang-Pei, WANG Guo-Sheng, SHAN Shu-Guang, QIAN Long   

  1. Department of Rheumatology, Anhui Provincial Hospital, Hefei 230001, Anhui
  • Received:2002-08-31 Revised:2002-12-05 Online:2003-04-26 Published:2020-11-25

摘要: 目的: 比较阿克他利和甲氨喋呤(MTX) 治疗活动期类风湿关节炎(RA) 的疗效及安全性。方法: 采用随机、单盲、对照方法, 选择疾病活动期RA患者75 例。治疗组(45 例) 阿克他利100 mg, 每天3次;对照组(30 例) 用MTX10 mg·wk-1。12 wk 为一疗程。结果: 阿克他利与MTX 均能显著改善RA 患者的症状、体征及实验室指标。治疗组与对照组在12 wk 总有效率分别为73.3%和83.3%。两组疗效在12 wk 时无显著的统计学意义(P >0.05)。治疗组有2 例(4.4%) 发生与药物有关的不良反应, 程度较轻。对照组有7 例(23.3%) 发生不良反应。其中2 例因不良反应而停药, 阿克他利耐受性好于MTX(P <0.05)。结论: 阿克他利对RA 患者有良好的治疗作用且副作用小。

关键词: 药效学, 关节炎, 类风湿, 阿克他利, 甲氨喋呤

Abstract: AIM: To compare the effectiveness and safety of actarit (ACT) versus methotrexate (MTX) in patients with active rheumatoid arthritis (RA). METHODS: 75 RA patients randomly assigned to receive ACT (n=45) or MTX (n=30).The patients in the ACT group received ACT 300 mg·d -1 and in the MTX group receivedMTX 10mg per week.The total courses were 12 weeks. RESULTS: The total effective rates of the ACT group and the MTX group were 73.3%and 83.3% at 12 weeks, respectively.There was no statistical significance between the two groups in the effectiveness (P >0.05). The adverse reaction rate was 4.4%(2 case) in the ACT group and 10%(7cases) inMTX group.The adverse reactions were more tolerable in ATC group than that in MTX group (P <0.05). CONCLUSION: ATC is an effective and more safe drug for patients with active rheumatoid arthritis.

Key words: pharmacodynamics, arthritis, rheumatoid, actarit, methotrexate

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