硝普钠对老年人充血性心力衰竭患者心功能及NO、LPO 和ANF 的影响

中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (3): 311-313.

硝普钠对老年人充血性心力衰竭患者心功能及NO、LPO 和ANF 的影响

李士玉, 马玉玲¹, 郭向杰, 李治红, 冯国伟

济宁医学院附属医院急诊科; ¹生化教研室, 济宁 272029, 山东

收稿日期:2002-12-18 修回日期:2003-01-17 出版日期:2003-06-26 发布日期:2020-11-25
通讯作者: 李士玉, 男, 教授, 主要从事内科危重病及冠心病的临床研究工作。Tel:0537-2903246 E-mail:lizhihong123@21cn.com

Effects of sodium nitroprusside on cardiac function and the level of nitric oxide, lipid peroxide and atrial natriuretic factor of the elderly patients with congestive heart failure

LI Shi-Yu, MA Yu-Ling¹, GUO Xiang-Jie, LI Zhi-Hong, FENG Guo-Wei

Department of Emergency of the Affiliated Hospital, ¹Department of Biochemistry, Jining Medical University, Jining 272029, Shandong

Received:2002-12-18 Revised:2003-01-17 Online:2003-06-26 Published:2020-11-25

摘要/Abstract

摘要： 目的: 观察硝普钠对老年人CHF 患者心功能及NO、LPO 和ANF 的影响。方法: 100 例60 岁以上CHF 患者随机分为硝普钠组和硝酸甘油组, 硝普钠组应用硝普钠20 mg, 5 %GS100 ml 静滴, 开始剂量为10~20 μg·min^-1, 效果不佳时剂量递增5~10 μg,最大剂量<100 μg·min^-1;硝酸甘油组应用硝酸甘油20 mg, 5 %GS 100 ml 静滴, 均为每日1 次, 疗程5~7d。结果: 硝普钠组总有效率为96 %, 硝酸甘油组为68 %, 两组治疗后心率血压下降、LVEF 及CO 均增加, LPO、ANF 下降, NO 水平上升, 两组比较, 硝普钠组明显优于硝酸甘油组, P <0.01。结论: 硝普钠对老年人CHF 疗效显著, 不良反应较少, 对常规治疗效果不佳的老年人CHF 患者, 可应用硝普钠治疗。

关键词: 药效学, 硝普钠, 老年人, 充血性心力衰竭, 一氧化氮, 过氧化脂质, 心钠素

Abstract: AIM: To observe effects of sodium nitroprusside on cardiac function and the level of nitric oxide (NO), lipid peroxide (LPO) and atrial natriuretic factor (ANF) of the elderly patients with congestive heart failure (CHF). METHODS: 100 patients with CHF who were over sixty years old were randomized to sodium nitroprusside group and nitroglycerine group.The patients in nitroprusside group received intravenous drip of 20 mg sodium nitroprusside +5 %GS100 ml once a day, the basic drip rate of sodium nitroprusside was 10 -20 μg·min^-1;if the effects was bad, then the incremental increases of drip rate was 5 -10 μg·min^-1, but the basic drip rate of sodium nitroprusside was less than 100 μg·min^-1.The patients in nitroglycerine group received intravenous drip of 20 mg nitroglycerine +5 %GS 100 ml once a day;the course of therapy in each group was 5 -7 days. RESULTS: the general effective rate in sodium nitroprusside group was 96 %, and that in nitroglycerine group was 68 %.After treatment, in each group, heart rate and blood pressure were decreased, LVEF and CO increased, the level of LPO and ANF were decreased, the level of NO increased;but apparently the curative effects of sodium nitroprusside group was much better than that of nitroglycerine group (P <0.01). CONCLUSION: Sodium nitroprusside has remarkable curative effects in elderly patients with CHF and few side effects;and the elderly patients with CHF, failed to conventional treatment, can be treated by sodium nitroprusside.

Key words: pharmacodynamics, sodium nitroprusside, the elderly, congestive heart failure, nitric oxide, lipid peroxide, atrial natriuretic factor

中图分类号:

李士玉, 马玉玲, 郭向杰, 李治红, 冯国伟. 硝普钠对老年人充血性心力衰竭患者心功能及NO、LPO 和ANF 的影响[J]. 中国临床药理学与治疗学, 2003, 8(3): 311-313.

LI Shi-Yu, MA Yu-Ling, GUO Xiang-Jie, LI Zhi-Hong, FENG Guo-Wei. Effects of sodium nitroprusside on cardiac function and the level of nitric oxide, lipid peroxide and atrial natriuretic factor of the elderly patients with congestive heart failure[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2003, 8(3): 311-313.

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