欢迎访问《中国临床药理学与治疗学》杂志官方网站,今天是

中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (3): 314-316.

• 研究原著 • 上一篇    下一篇

小牛血去蛋白提取物对胃溃疡患者的疗效评价

才宁, 王洪新, 闫飞1, 王志义2, 禹向国2, 唐一超2   

  1. 锦州医学院生物技术研究所, 锦州 121001, 辽宁; 1锦州监狱医院内科, 锦州121001, 辽宁; 2锦州石化公司职工医院内科, 锦州 121001, 辽宁
  • 收稿日期:2002-10-31 修回日期:2002-11-19 出版日期:2003-06-26 发布日期:2020-11-25
  • 通讯作者: 才宁, 女, 硕士, 现在锦州石化公司职工医院内科。Tel:0416-4159127
  • 作者简介:王洪新, 男, 医学博士, 硕士生导师, 教授。Tel:0416-4580209 E-mail:jyhxwang@hotmail.com

Efficacy of deproteinised calf blood extract in treatment of patients with peptic ulcer disease

CAI Ning, WANG Hong-Xin, YAN Fei1, WANG Zhi-Yi2, YU Xiang-Guo2, TANG Yi-Chao2   

  1. Bio-Technology Institute, Jinzhou Medical College, Jinzhou 121001, Liaoning; 1Department of Medicine, Prison Hospital, Jinzhou 121001, Liaoning; 2Department of Medicine, Shihua Hospital, Jinzhou 121001, Liaoning
  • Received:2002-10-31 Revised:2002-11-19 Online:2003-06-26 Published:2020-11-25

摘要: 目的: 探讨小牛血去蛋白提取物(DCBE) 对胃溃疡的治疗作用。方法: 选择年龄20 ~ 70 岁之间, 经胃镜检查确诊为活动期胃溃疡的住院患者60例。治疗组32 例采用静脉滴注DCBE (800 mg, qd)和法莫替丁(100 mg, bid) 治疗;对照组28 例采用静脉滴注法莫替丁(100 mg, bid) 单独治疗。用药2、4wk 行胃镜检查, 观察自觉缓解症状、时间、愈合率和总有效率。结果: 治疗组自觉症状缓解时间明显缩短;给药后2、4 wk 治疗组及对照组胃镜检查溃疡愈合率分别为78.1 %, 46.4 %及84.4 %, 71.4 %。结论: DCBE 能显著促进胃溃疡的愈合。

关键词: 药效学, 小牛血去蛋白提取物, 法莫替丁, 胃溃疡

Abstract: AIM: To observe the efficacy of deproteinised calf blood extract (DCBE) in the treatment of patients with peptic ulcer disease. METHODS: 60 patients were randomly divided into two groups.Treating group (n =32) received DCBE (800 mg, qd) and famotidine (100 mg, bid) and control group (n =28) received famotidine (100 mg bid).These treatments lasted for four weeks.The efficacy was determined by gastroendoscopy. RESULTS: The ulcer healing rates were 78.1 % and 46.4 %for 2 wk, and 84.4 % and 71.4 % for 4 wk in treating group and control group, respectively. CONCLUSION: DCBE has a significant effect in the treatment of patients with peptic ulcer disease.

Key words: pharmacodynamics, deproteinised calf blood extract, famotidine, peptic ulcer

中图分类号: