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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (3): 317-319.

• 研究原著 • 上一篇    下一篇

洛沙坦抗小鼠艾氏腹水癌的作用

陈方, 吴铁   

  1. 广东医学院药理教研室, 湛江 524023, 广东
  • 收稿日期:2002-11-28 修回日期:2003-01-05 出版日期:2003-06-26 发布日期:2020-11-25
  • 作者简介:陈方, 男, 讲师, 在读硕士, 主要从事抗肿瘤药和抗糖尿病药研究。Tel:0759-2388588-1 E-mail:gdmc.cf@163.com;吴铁, 男, 教授, 硕士生导师, 主要从事抗肿瘤药、抗糖尿病药和抗骨质疏松药研究。

Antitumor effects of losartan in EAC mice

CHEN Fang, WU Tie   

  1. Department of Pharmacology, Guangdong Medical College, Zhanjiang 524023, Guangdong
  • Received:2002-11-28 Revised:2003-01-05 Online:2003-06-26 Published:2020-11-25

摘要: 目的: 观察洛沙坦(losartan) 对抗小鼠艾氏腹水癌(EAC) 的作用。方法: 采用昆明种小鼠, 随机分组进行实验, 分别观察洛沙坦对体内艾氏腹水癌实体瘤的抑瘤率和艾氏腹水癌生存期延长率的作用,并与5-FU 和生理盐水对照。结果: 洛沙坦(12.5mg·kg-1) 对小鼠体内艾氏腹水癌实体瘤有显著的抑瘤作用, 抑瘤率达46.3 %, 阳性对照药5-FU(5 mg·kg-1) 的抑瘤率为31.5 %;但洛沙坦对艾氏腹水癌生存期延长率无明显影响, 阳性对照药5-FU(5 mg·kg-1) 生存期延长率为42.9 %。结论: 洛沙坦对动物移植性肿瘤艾氏腹水癌(EAC) 的实体瘤有显著的抑瘤作用, 但对腹水癌无提高生存期延长率的作用, 推测其抗肿瘤作用可能是通过抑制肿瘤血管生长而发挥作用。

关键词: 药理学, 洛沙坦, 5-FU, 艾氏腹水癌, 抗肿瘤

Abstract: AIM: To study the antitumor effects of losartan in EAC mice. METHODS: The inhibitory rates of tumor growth and the ratio of extending viability were observed in EAC mice in three groups given losartan, 5- FU and NS, respectively. RESULTS: Comparing with the control groups, the inhibition to tumor growth was 46.3 % in losartan (12.5 mg·kg -1) group.But losartan did not lengthen life time in EAC mice.The inhibition to tumor growth was was 31.5 % in 5-FU (5 mg·kg -1) group. CONCLUSION: Losartan can inhibit the tumor growth of EAC, but not lengthen life time of the animals.

Key words: pharmacology, losartan, 5-FU, EAC, antitumor effect

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