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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (3): 323-325.

• 研究原著 • 上一篇    下一篇

虎参痛风丸在小鼠的镇痛作用

杨洪发, 宋文冲, 王燕燕, 钱京萍, 陈超   

  1. 三峡大学第一临床医学院药剂科, 宜昌 443003, 湖北
  • 收稿日期:2002-10-14 修回日期:2002-11-07 出版日期:2003-06-26 发布日期:2020-11-25
  • 通讯作者: 杨洪发, 男, 副主任药师, 硕士生导师, 药剂科主任, 宜昌市药学会副理事长, 研究方向为中草药制剂。
  • 作者简介:宋文冲, 男, 硕士研究生, 研究方向:免疫药理学。陈超, 男, 教授, 硕士生导师, 研究方向:中药药理学。Tel:0717-6482967 E-mail:chaochen1954@163.com

Analgesic effects of hushentongfengwan in mice

YANG Hong-Fa, SONG Wen-Chong, WANG Yan-Yan, QIAN Jing-Ping, CHEN Chao   

  1. The First Clinical Medical College, Three Gorges University, Yichang 443003, Hubei
  • Received:2002-10-14 Revised:2002-11-07 Online:2003-06-26 Published:2020-11-25

摘要: 目的: 探讨虎参痛风丸的镇痛效果及急性毒性。方法: 分别观察虎参痛风丸高、中、低三个剂量组对小鼠冰醋酸所致的扭体反应、热板法致痛的影响。观察最大浓度药液对小鼠的急性毒性反应。结果: 虎参痛风丸能显著抑制小鼠冰醋酸所致的扭体反应、减轻热板刺激所致的疼痛;虎参痛风丸无明显急性毒性反应。结论: 虎参痛风丸有明显的镇痛作用且无明显的急性毒性反应。

关键词: 药效学, 虎参痛风丸, 镇痛, 急性毒性实验

Abstract: AIM: To evaluate the analgesic effects and acute toxicity of hushentongfengwan (Hus). METHODS: The analgesic effects were tested by writhing reaction and hot-plate method and acute toxicity was observed in mice. RESULTS: Hus could restrain writhing reaction caused by acetic acid glacial, lighten the pain caused by hot-plate, and it did not show any reactions of acute toxicity. CONCLUSION: Hus had significant analgesic action.

Key words: pharmacodynamics, analgesia, acute toxicity

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