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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (3): 326-328.

• 研究原著 • 上一篇    下一篇

咪唑斯汀治疗慢性荨麻疹临床疗效评价及对血清IL-4 水平的影响

慈超, 马小玲, 孟庆琴   

  1. 皖南医学院弋矶山医院皮肤科, 芜湖 241001, 安徽
  • 收稿日期:2002-12-21 修回日期:2003-01-10 出版日期:2003-06-26 发布日期:2020-11-25
  • 通讯作者: 慈超, 男, 主治医师, 主要从事临床皮肤性病研究。Tel:0553-5738856-2216

Efficacy of mizolastine in the treatment of patients with chronic urticarial and the change of serum IL-4

CI Chao, MA Xiao-Ling, MENG Qing-Qin   

  1. Department of Dermatology, Yijishan Hospital, Wannan Madical College, Wuhu 241001, Anhui
  • Received:2002-12-21 Revised:2003-01-10 Online:2003-06-26 Published:2020-11-25

摘要: 目的: 评价咪唑斯汀治疗慢性荨麻疹的疗效,探讨IL-4 在慢性荨麻疹发病中的作用。方法: 对32例慢性荨麻疹患者用咪唑斯汀治疗, 评价疗效, 记录不良反应。同时用ELISA 法检测慢性荨麻疹患者治疗前后及正常人血清IL-4 的水平。结果: 治疗1、2wk 后总有效率分别为62.5 %、84.4 %(P <0.05),不良反应3 例。治疗前血清IL-4 水平较正常人明显升高(P <0.01);治疗后IL-4 水平下降(P <0.01),与正常人比较差异不甚明显(P >0.05)。结论: 咪唑斯汀是一种有效、安全的治疗慢性荨麻疹的药物,能降低慢性荨麻疹患者血清IL-4 的水平。

关键词: 药效学, 咪唑斯汀, 慢性荨麻疹, 疗效评价, 白细胞介素4

Abstract: AIM: To evaluate the effect of mizolastine in patients with chronic urticaria and to explore the role of IL-4 in the process of chronic urticaria. METHODS: 32 cases of chronic urticaria were treated with mizolastine, and the therapeutic effects and the side-effect were evaluated.The serum IL-4 levels were tested by ELISA. RESULTS: The total effective rates were 62.5 % and 84.4 % (P <0.05) at the end of 1 wk and 2 wk, respectively.The side-effects were found in 3 cases (9.4 %).The average levels of serum IL-4 before treatment were higher than those in controls (P <0.01), but after treatment were not (P >0.05), and before treatment were significantly higher than those after treatment (P <0.01). CONCLUSIONs: Mizolastine is an effective and safe drug in the treatment of patients with chronic urticaria and the serum level of IL-4 decreases.

Key words: pharmacodynamics, mizolastine, chronic urticaria, evaluation, IL-4

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