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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (5): 481-484.

• 综述与讲座 •    下一篇

谷胱甘肽在帕金森病治疗中的研究进展

胡军 综述, 胡刚 审校   

  1. 南京医科大学药理学与神经生物学系,南京 210029,江苏
  • 收稿日期:2003-05-19 修回日期:2003-06-12 出版日期:2003-10-26 发布日期:2020-11-19
  • 通讯作者: 胡刚,男,博士,博士生导师,研究方向:神经退行性疾病的实验治疗学研究。Tel:025-6663108 E-mail:ghu@njmu.edu.cn
  • 基金资助:
    国家自然科学基金项目(No39970846)

Progress in the study of glutathione inParkinson' s disease

HU Jun, HU Gang   

  1. Department ofPharmacology& Neurobiology,Nanjing Medical University,Nanjing 210029,Jiangsu,China
  • Received:2003-05-19 Revised:2003-06-12 Online:2003-10-26 Published:2020-11-19

摘要: 大量研究表明过多的活性氧簇与帕金森病(Parkinson's disease,PD)的发生、发展密切相关。PD患者机体长期处于氧化应激状态,去除活性氧簇在脑内的毒性作用便成为治疗该病的一条重要途径,而抗氧化剂谷胱甘肽在此过程中发挥着极其关键的作用。提高谷胱甘肽在脑内的浓度或应用谷胱甘肽的类似物、前体来防治PD 及其它神经退行性疾病,已经成为当前药物研制的一个重要靶点。

关键词: 药理学, 综述, 帕金森病, 氧化应激, 谷胱甘肽, 神经退行性疾病

Abstract: In recent years,there is increasing evidence that thePathogenesis ofParkinson' s disease (PD)may involve the more generation of reactive oxygen species,and investigations onPatients have shown thatPD is under a status of oxidative stress.The defense against the toxic effects of reactive oxygen species is an essential task within the brain.An important component of the cellular detoxification of reactive oxygen species is the antioxidant glutathione.Consequently,it seems reasonable toPropose that increase of brain concentrations of glutathione including glutathione analogs orPrecursors could be very effective in diminishing the cumulative effects of oxidative damage,and have been investigated asPotential therapeutic targets in the treatment andPrevention ofPD or other neurodegenerative disease.

Key words: pharmacology, review, Parkinson' s disease, oxidative stress, glutathione, neurodegenerative disease

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