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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (6): 677-679.

• 研究原著 • 上一篇    下一篇

托吡酯单药治疗不同类型癫痫的疗效评价

曹辉, 管青山   

  1. 南京医科大学附属脑科医院神经内科,南京 210029,江苏
  • 收稿日期:2003-08-26 出版日期:2003-12-26 发布日期:2020-11-19
  • 通讯作者: 曹辉,男,主治医生,研究方向:脑血管病及癫痫。Tel:025-3700011-6372 E-mail:caohui6345@163.com

Efficacy evaluation of topiramate in treatment ofPatients with different types of epilepsy

CAO Hui, GUAN Qing-Shan   

  1. Department of Neurology,Brain Hospital Affiliated to Nanjing Medical University,Nanjing,210029,J iangsu,China
  • Received:2003-08-26 Online:2003-12-26 Published:2020-11-19

摘要: 目的 进行托吡酯(妥泰)单药治疗癫痫的疗效评价。方法 选择60 例癫痫患者,应用托吡酯单药治疗20 周。入组前观察并记录基础发作频率。剂量从25 mg·d-1开始,每周增加25 mg,共8 周,达到有效剂量或200 mg·d-1后维持治疗12 周,观察癫痫发作频率变化及不良反应。结果 发作完全控制31 例(51 .7%),发作减少≥75% 14 例(23 .3%),发作减少≥50% 4 例(6 .7%),发作减少<50% 11 例(18 .3%)。发作频率低,病程短的病例,完全控制比例高。治疗过程中无严重不良反应。结论 托吡酯可作为初发各型癫痫病人常规单药治疗药物,且耐受性、安全性好。剂量应充分考虑个体化的原则,一般病人用量不超过100 mg·d-1

关键词: 药效学, 托吡酯, 癫痫, 单药治疗, 疗效评价

Abstract: AIM: To evaluation the efficacy dosages of topiramate(TMP)in treatment ofPatients with different types of epilepsy.METHODS: The seizure rate in baselinePhase ofPatients with epilepsy were observed and recorded before treatment of topiramate as monotherapy for 20 weeks.The TMPstarting dosage was 25 mg·d-1,and then increased to 25 mg·d-1each week for 8 weeks until effective dosage or 200 mg·d-1for 12 weeks,and the change of seizure frequency and adverse reactions were recorded.RESULTS: The seizure in 31 cases(51.7%)was totally controlled,seizure reduction of≥75%was in 14 cases(23.3%),≥50%was in 4 cases(6.7%),and<50% was in 11 cases(18.3%).ThePatients with shorter duration andlowered seizure rate showed better effect,and TMPwas extremely effective at controlling a variety of seizures without causing excessive seizure aggravation.There was no severe bad reaction during the course of treatment.CONCLUSION: TMPas monotherapy is effective to different types of epilepsy,and it is also well-tolerated and safety.But the dosage of TMPshould be adjusted for eachPatient,and generally the maximum dosage should not be over 100 mg·d-1.

Key words: pharmacodynamics, topiramate, epilepsy, monotherapy, efficacy evaluation

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