欢迎访问《中国临床药理学与治疗学》杂志官方网站,今天是

中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (6): 696-698.

• 研究原著 • 上一篇    下一篇

潘托拉唑与其他药物治疗消化性溃疡对照研究Meta分析

李见春, 李娟1, 田学丰2   

  1. 日照市人民医院药剂科,日照 276826,山东;
    1安徽省药物临床评价中心,芜湖 241001,安徽
  • 收稿日期:2002-12-23 修回日期:2003-06-28 出版日期:2003-12-26 发布日期:2020-11-19
  • 通讯作者: 李见春,男,主要从事临床药学工作。Tel:0633-3365350
  • 作者简介:2 皖南医学院实习生。

Meta-analysis of effectiveness ofPantoprazole and other drugs in treatment ofPatients with activePeptic ulcer

LI Jian-Chun, LI Juan1, TIAN Xue-Feng2   

  1. Department ofPharmacy,the RezhaoPeople' s Hospital,Rezhao 276826,Shandong,China;
    1AnhuiProvincial Center for Drug Clinical Evaluation&Yijishan Hospital of Wannan Medical College,Wuhu 241001,Anhui,China
  • Received:2002-12-23 Revised:2003-06-28 Online:2003-12-26 Published:2020-11-19

摘要: 目的 分析潘托拉唑与其他药物治疗消化性溃疡疗效的差异。方法 应用Meta 分析对9 项研究消化性溃疡的效果进行同质性检验和合并效应量的估计。结果 (1)同质性检验:χ2=14 .7099,自由度为8,P>0 .05 。(2)合并效应量的估计:OR合并=2 .94,OR合并95%可信区间为2 .098 ~ 4 .128 。OR合并的检验:χ2=39 .14,P<0 .01 。结论 潘托拉唑治疗消化性溃疡的疗效显著优于目前常用药物,但在治疗剂量、适应症、给药途径及用药时限等方面与临床疗效的关系有待进一步研究。

关键词: 疗效评价, Meta分析, 消化性溃疡, 潘托拉唑

Abstract: AIM: To analyze the efficacy betweenPantoprazole and other drugs in treatment ofPatients with activePeptic ulcer.METHODS: The efficacies ofPantoprazole or other drugs were analyzed by Meta-analysis in homogeneity test and combined test in 9 studies in treating activePeptic ulcer.RESULTS:(1)Homogeneity test showed that the cited studies were homogeneous withχ2=14.710 andP>0.05 ;and(2)in combined test,the combined OR=2.94 and its 95% confidence interval was in the range of 2.098 -4.128(χ2=39.14,P<0.01).CONCLUSION: The effectiveness ofPantoprazole is significantly superior to the medications used atPresent in treatment of activePeptic ulcer.It is necessary to further investigate the relationshiPbetween its clinical efficacy and the dosages,and betweenProtocols of drug administration and indications.

Key words: efficacy evaluation, Meta-analysis, activePeptic ulcer, pantoprazole

中图分类号: