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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (6): 704-705.

• 会议·研究原著 • 上一篇    下一篇

氨氯地平联用依那普利治疗老年高血压病疗效评价

钟绿萍   

  1. 龙岩市第二医院老年科,龙岩 364000,福建
  • 收稿日期:2003-06-14 修回日期:2003-07-02 出版日期:2003-12-26 发布日期:2020-11-19
  • 通讯作者: 钟绿萍,女,主治医师,研究方向:老年心脑血管疾病。Tel:0597-2300284  E-mail:fangqj@sohu.com

Clinical evaluation of amlodipine combined with enalapril in treatment of elderlyPatients with hypertension

ZHONGLU-Ping   

  1. Department of Elderly,the Second Hospital oflongyan,longyan 364000,Fujian,China
  • Received:2003-06-14 Revised:2003-07-02 Online:2003-12-26 Published:2020-11-19

摘要: 目的 观察氨氯地平与依那普利单用及联合应用治疗老年原发性高血压患者的临床疗效。方法 100 例老年高血压病患者随机分为2 组。(1)氨氯地平组(n=50):口服氨氯地平5 mg,每日1 次;(2)依那普利组(n=50):口服依那普利10 mg,每日1 次。两组用药2 wk后,降压未达显效者,氨氯地平组联用依那普利10 mg,每日1 次;依那普利组联用氨氯地平5 mg,每日1 次,再观察2 wk 。比较两组治疗前、后2 、4 wk 血压情况。结果 氨氯地平组2 、4 wk 的降压总有效率分别为62%、94%;依那普利组2 、4 wk 的降压总有效率分别为60%、96%,两组组内比较P<0 .01,组间比较无统计学意义(P>0 .05)。两组均有轻度不良反应。结论 氨氯地平或依那普利单用治疗老年原发性高血压有效,两药联用可提高降压效果。在单一用药基础上加药,药物时序不同对疗效影响不大。

关键词: 药效学, 氨氯地平, 依那普利, 老年, 高血压病

Abstract: AIM: To investigate the efficacy of amlodipine,enalapril,and amlodipinePlus enalapril on elderlyPatients with hypertension.METHODS: 100 cases were randomly assigned to two groups:50 cases treated with 5 mg qd of amlodipine(amlodipine group),and another 50 cases treated with 10 mg qd enalapril of(enalapril group).After two weeks,the cases that bloodPressure was not decreased significantly were added enalapril 10 mg qd in amlodipine grouPand added amlodipine 5mg qd in enalapril grouPfor two weeks.RESULTS: After two weeks and four weeks,the total effective rates were 62% and 94%(P<0.01)in amlodipine group,respectively,and were 60% and 96%(P<0.01)in enalapril group.No difference showed in the two groups.No severe side effects were found.CONCLUSIONS: Amlodipine,enalapril,and amlodipinePlus enalapril can effectively decreased bloodPressure in the elderlyPatients with hypertension.

Key words: pharmacodynamics, amlodipine, enalapril, elderly, hypertension

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