关键词: 毒代动力学, 系统暴露量, 溴泰君, 阿霉素, 联合用药

Abstract: AIM: To study the toxicokinetics after single or combination administration of bromotetrandrine (W198) and adriamycin in beagle dogs. METHODS: The concentrations of W198 and adriamycin in biological samples were determined by HPLC with ultraviolet and fluorescence detection. RESULTS: After successive in-travenous administration of 15 mg·kg^-1 W198, the values of AUC_0-24h of W198 were 6.15±0.66, 26.55±9.43 and 33.63±2.31 mg·h^-1·L^-1 for 1st, 3rd and 72nd administration, respectively, After successive in-travenous administration of 15 mg·kg^-1 adriamycin, the values of AUC_0-24h of adriamycin were 0.70±0.21 and 1. 19±0.19 mg·h^-1·L^-1 for 1st and 3rd administration, respec-tively.After successive intravenous combination administration of W198 and adriamycin, the values of AUC_0-24h of W198 were 25.52±6.04 and 42.60±4.14 mg·h^-1·L^-1, and the AUC_0-24h of adriamycin were 0.39±0.05 and 0.77±0.19 mg·h^-1·L^-1 for 3rd administration of W198 combined with 1st administration of adriamycin and 39th administration of W198 combined with 3rd administration of adriamycin, respectively. CONCLUSION: Both bro-motetrandrine and adriamycin have significantly accumula-tion effects in beagle dogs after successive intravenous ad-ministration, and bromotetradrine can reduce the systemic exposure of adriamycin after co-administration of the two drugs.

Key words: toxicokinetics, systemic exposure, bro-motetrandrine, adriamycin, co-administration